Transplantation of human embryonic stem cell-derived endothelial cells for vascular diseases.
Transplantation of human embryonic stem cell-derived endothelial cells for vascular diseases.
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DOI：
10.1002/jcb.22003
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发表时间：
2009-02-01
影响因子：
4
通讯作者：
Wui, Joseph C.
中科院分区：
文献类型：
--
作者：
Li, Zongjin;Han, Zhongchao;Wui, Joseph C.
利用内皮细胞治疗血管生成/血管生成缺血性疾病已经导致探索人类胚胎干细胞（hESCs）作为内皮祖细胞的潜在无限来源。hesc及其衍生的内皮细胞（hESC-ECs）具有自我更新和多能性的能力，可能比从患病人群中获得的其他内皮细胞更有利。然而，hESC-ECs移植后分化效率不高，体内功能特征不明确，这给其未来的临床应用带来了重大挑战。本文将重点介绍hESCs的分化途径及其在血管疾病中的治疗潜力，以及通过分子成像技术监测移植细胞的命运。最后，我们将讨论提高hesc - ec移植效率的细胞增强策略。
Using endothelial cells for therapeutic angiogenesis/vasculogenesis of ischemia diseases has led to exploring human embryonic stem cells (hESCs) as a potentially unlimited source for endothelial progenitor cells. With their capacity for self-renewal and pluripotency, hESCs and their derived endothelial cells (hESC-ECs) may be more advantageous than other endothelial cells obtained from diseased populations. However, hESC-ECs’ poor differentiation efficiency and poorly characterized in vivo function after transplantation present significant challenges for their future clinical application. This review will focus on the differentiation pathways of hESCs and their therapeutic potential for vascular diseases, as well as the monitoring of transplanted cells’ fate via molecular imaging. Finally, cell enhancement strategies to improve the engraftment efficiency of hESC-ECs will be discussed.
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影响因子：
5.2
作者：
Li, Zongjin;Suzuki, Yoriyasu;Wu, Joseph C.
通讯作者：
Wu, Joseph C.
影响因子：
37.8
作者：
Iba, O;Matsubara, H;Iwasaka, T
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Iwasaka, T
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4
作者：
Peiffer, Isabelle;Belhomme, Denis;Hatzfeld, Jacques A.
通讯作者：
Hatzfeld, Jacques A.
影响因子：
37.8
作者：
Li, Zongjin;Wu, Jenny C.;Wu, Joseph C.
通讯作者：
Wu, Joseph C.
影响因子：
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作者：
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通讯作者：
Margolis, Leonid