Anesthesia and Cancer, Friend or Foe? A Narrative Review.
Anesthesia and Cancer, Friend or Foe? A Narrative Review.
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麻醉和癌症，朋友还是敌人？叙事评论。
DOI：
10.3389/fonc.2021.803266
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发表时间：
2021
影响因子：
4.7
通讯作者：
Jevtovic-Todorovic V
中科院分区：
文献类型：
--
作者：
Montejano J;Jevtovic-Todorovic V
癌症仍然是全世界死亡的主要原因，每年报告有近 1000 万人死亡。由于我国人口中高龄人群的增长，预计从现在到 2035 年，新诊断的癌症病例数量可能会达到 2400 万，这在相对较短的时间内出现了惊人的增长。对于许多实体瘤来说，手术切除联合化疗是实现潜在治愈的最佳可行方法，这导致近 80% 的癌症患者在其疾病过程中至少接受过一次外科手术。在手术干预期间，全身麻醉可能是漫长、复杂的，并且常常涉及多种方式，从而产生了一个重要问题：麻醉在原发性复发或转移性转化中可能发挥的作用（如果有的话）。围手术期表现出的应激和炎症反应的许多成分可能导致癌症生长和侵袭。用于诱导和维持全身麻醉的药物与免疫和神经内分泌系统具有不同的相互作用，并可能影响手术期间的应激反应。因此，关于有助于减弱交感神经和/或促炎症反应，同时调节细胞因子释放和转录因子/癌基因的最佳麻醉类型的争论仍然是最前沿的。这可能不仅在术中而且在术后恢复阶段影响诱导癌细胞的存活和迁移能力。最终的问题是麻醉的选择如何以及是否会影响癌症手术的结果，主要考虑两种方法，即局部麻醉和全身麻醉以及常用的各种催眠药、镇痛药和抗交感神经药。在这篇综述中，我们将讨论有关麻醉在癌症手术期间可能发挥的作用的最新信息，特别关注原发性复发和转移。
Cancer remains the leading cause of death worldwide with close to 10 million deaths reported annually. Due to growth of the advanced age cohort in our population, it is predicted that the number of new cancer cases diagnosed between now until 2035 is to reach potentially 24 million individuals, a staggering increase in a relatively short time period. For many solid tumors, surgical resection along with chemotherapy is the best available approach to a potential cure which leads to almost 80% of cancer patients undergoing at least one surgical procedure during the course of their disease. During surgical intervention, the exposure to general anesthesia can be lengthy, complex and often involves various modalities resulting in an important question as to the role, if any, anesthesia may play in primary recurrence or metastatic conversion. Many components of the stress and inflammatory responses exhibited in the perioperative period can contribute to cancer growth and invasion. The agents used to induce and maintain general anesthesia have variable interactions with the immune and neuroendocrine systems and can influence the stress response during surgery. Thus, debating the best type of anesthesia that would help to attenuate sympathetic and/or pro-inflammatory responses while modulating cytokine release and transcription factors/oncogenes remains at the forefront. This may affect inducible cancer cell survival and migratory abilities not only intra-operatively, but also during the immediate post-operative phase of recovery. The ultimate question becomes how and whether the choice of anesthesia may influence the outcomes of cancer surgery with two major approaches being considered, i.e., regional and general anesthesia as well as the various hypnotics, analgesics and sympatholytics commonly used. In this review, we will address the latest information as to the role that anesthesia may play during cancer surgery with specific focus on primary recurrence and metastasis.
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影响因子：
2.9
作者：
Ji W;Zhang X;Sun G;Wang X;Liu J;Bian J;Bo L
通讯作者：
Bo L
DOI：
10.4103/joacp.joacp_299_16
发表时间：
2017-07
期刊：
Journal of anaesthesiology, clinical pharmacology
影响因子：
--
作者：
Cata JP;Singh V;Lee BM;Villarreal J;Mehran JR;Yu J;Gottumukkala V;Lavon H;Ben-Eliyahu S
通讯作者：
Ben-Eliyahu S
影响因子：
9.8
作者：
Hayden, Jane M.;Oras, Jonatan;Gupta, Anil
通讯作者：
Gupta, Anil
影响因子：
6.2
作者：
Ghirardi, Valentina;Ronsini, Carlo;Fagotti, Anna
通讯作者：
Fagotti, Anna
视频辅助胸腔手术治疗非小细胞肺癌后静脉注射利多卡因对血清白细胞介素 17 的影响：一项随机、双盲、安慰剂对照试验
DOI：
10.2147/dddt.s316804
发表时间：
2021
期刊：
Drug design, development and therapy
影响因子：
--
作者：
Hou YH;Shi WC;Cai S;Liu H;Zheng Z;Qi FW;Li C;Feng XM;Peng K;Ji FH
通讯作者：
Ji FH