Evaluation of hemostatic changes using n thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery.
Evaluation of hemostatic changes using n thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery.
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DOI：
10.1590/s0100-879x2012007500095
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Okçu G
中科院分区：
文献类型：
--
作者：
Topçu I;Civi M;Oztürk T;Keleş GT;Coban S;Yentür EA;Okçu G
采用血栓弹力图（TEG）测定乳酸林格液、6%羟乙基淀粉（130/0.4）或4%琥珀酰明胶溶液对围术期凝血功能的影响。75例患者（阿萨I-III）在硬膜外麻醉下接受主要骨科手术，纳入本研究。将患者随机分为3组，每组25例，给予维持液体：RL组（乳酸林格氏液）、HES组（6%羟乙基淀粉130/0.4）和JEL组（4%佳乐施溶液）。在硬膜外麻醉前（t1，基线）、手术结束时（t2）和手术后24 h（t3）的围手术期采集血样。 记录TEG数据、反应时间（R）、凝血时间（K）、角度值（α）和最大振幅（MA）。所有患者的TEG参数均较正常值发生变化。RL组R、K时间较围术期缩短，α角、MA较围术期增加（P < 0.05）。HES组R、K次数增加，α角、MA减小（P < 0.05）。JEL组R时间延长（P < 0.05），K时间、α角、MA无明显变化。在本研究中，RL、6% HES（130/0.4）和4% JEL溶液引起所有患者凝血系统的变化（通过TEG测量），但这些变化仍在正常范围内。
The effects of Ringer lactate, 6% hydroxyethyl starch (130/0.4) or 4% succinylated gelatin solutions on perioperative coagulability were measured by thromboelastography (TEG). Seventy-five patients (ASA I-III) who were to undergo major orthopedic procedures performed under epidural anesthesia were included in the study. Patients were randomly divided into three groups of 25 each for the administration of maintenance fluids: group RL (Ringer lactate), group HES (6% hydroxyethyl starch 130/0.4), and group JEL (4% gelofusine solution). Blood samples were obtained during the perioperative period before epidural anesthesia (t1, baseline), at the end of the surgery (t2), and 24 h after the operation (t3). TEG data, reaction time (R), coagulation time (K), angle value (α), and maximum amplitude (MA) were recorded. TEG parameters changed from normal values in all patients. In group RL, R and K times decreased compared to perioperative values while the α angle and MA increased (P < 0.05). In group HES, R and K times increased, however, the α angle and MA decreased (P < 0.05). In group JEL, R time increased (P < 0.05), but K time, α angle and MA did not change significantly. In the present study, RL, 6% HES (130/0.4) and 4% JEL solutions caused changes in the coagulation system of all patients as measured by TEG, but these changes remained within normal limits.
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DOI：
10.1111/j.1445-2197.1988.tb06236.x
发表时间：
1988-01-01
期刊：
Australian and New Zealand Journal of Surgery
影响因子：
--
作者：
DEANE S A;GAUDRY P L;READ C
通讯作者：
READ C
影响因子：
9.8
作者：
Mardel, SN;Saunders, FM;Ibbotson, RM
通讯作者：
Ibbotson, RM
影响因子：
10.7
作者：
Haas, T.;Preinreich, A.;Innerhofer, P.
通讯作者：
Innerhofer, P.
影响因子：
5.7
作者：
Innerhofer, P;Fries, D;Schobersberger, W
通讯作者：
Schobersberger, W
影响因子：
5.7
作者：
Niemi, TT;Suojaranta-Ylinen, RT;Kuitunen, AH
通讯作者：
Kuitunen, AH