Children's Oncology Group's 2013 blueprint for research: renal tumors.

Children's Oncology Group's 2013 blueprint for research: renal tumors.
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DOI:
10.1002/pbc.24419
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发表时间:
2013-06
影响因子:
3.2
通讯作者:
Perlman, Elizabeth J.
Perlman, Elizabeth J.
中科院分区:
医学3区
文献类型:
--
作者:
Dome, Jeffrey S.;Fernandez, Conrad V.;Mullen, Elizabeth A.;Kalapurakal, John A.;Geller, James I.;Huff, Vicki;Gratias, Eric J.;Dix, David B.;Ehrlich, Peter F.;Khanna, Geetika;Malogolowkin, Marcio H.;Anderson, James R.;Naranjo, Arlene;Perlman, Elizabeth J.

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肾恶性肿瘤是最常见的儿科癌症之一。最常见的是组织学良好的肾母细胞瘤(FHWT),其5年总生存率超过90%。其他儿童肾脏恶性肿瘤,包括间变性肾母细胞瘤、透明细胞肉瘤、恶性横纹肌样瘤和肾细胞癌,预后较差。最近的临床试验已经确定染色体1q的获得作为FHWT的预后标志物。即将进行的研究将根据这一点和其他新的生物标志物评估治疗调整。对于高危肾肿瘤,新的治疗方案将包括生物疗法。研究蓝图,从儿童肿瘤组的角度来看,提出。
Renal malignancies are among the most prevalent pediatric cancers. The most common is favorable histology Wilms tumor (FHWT), which has 5-year overall survival exceeding 90%. Other pediatric renal malignancies, including anaplastic Wilms tumor, clear cell sarcoma, malignant rhabdoid tumor, and renal cell carcinoma, have less favorable outcomes. Recent clinical trials have identified gain of chromosome 1q as a prognostic marker for FHWT. Upcoming studies will evaluate therapy adjustments based on this and other novel biomarkers. For high-risk renal tumors, new treatment regimens will incorporate biological therapies. A research blueprint, viewed from the perspective of the Children’s Oncology Group, is presented.
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