Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study.
Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study.
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DOI：
10.1126/sciadv.abc6457
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发表时间：
2020-11
期刊：
影响因子：
13.6
通讯作者：
Bernhardt BC
中科院分区：
文献类型：
--
作者：
Larivière S;Rodríguez-Cruces R;Royer J;Caligiuri ME;Gambardella A;Concha L;Keller SS;Cendes F;Yasuda C;Bonilha L;Gleichgerrcht E;Focke NK;Domin M;von Podewills F;Langner S;Rummel C;Wiest R;Martin P;Kotikalapudi R;O'Brien TJ;Sinclair B;Vivash L;Desmond PM;Alhusaini S;Doherty CP;Cavalleri GL;Delanty N;Kälviäinen R;Jackson GD;Kowalczyk M;Mascalchi M;Semmelroch M;Thomas RH;Soltanian-Zadeh H;Davoodi-Bojd E;Zhang J;Lenge M;Guerrini R;Bartolini E;Hamandi K;Foley S;Weber B;Depondt C;Absil J;Carr SJA;Abela E;Richardson MP;Devinsky O;Severino M;Striano P;Tortora D;Hatton SN;Vos SB;Duncan JS;Whelan CD;Thompson PM;Sisodiya SM;Bernasconi A;Labate A;McDonald CR;Bernasconi N;Bernhardt BC
人类癫痫综合征中的脑萎缩可以通过网络结构来解释，并且在枢纽区域最强。癫痫越来越多地被概念化为网络障碍。在这项横断面大型分析中，我们整合了神经影像学和连接体分析，以确定与来自19个国际站点的1021名癫痫成年人和1564名健康对照的萎缩模式的网络关联。在颞叶癫痫中，萎缩区域与高度互连的皮质中枢区域共定位，而特发性全身性癫痫则优先累及皮质下中枢。这些形态学异常被锚定到不同疾病震中的连接配置文件，指向颞叶癫痫的颞叶边缘皮质和特发性全身性癫痫的额中央皮质。年龄对萎缩的负面影响进一步揭示了颞叶连接体结构的强烈影响，但不是特发性全身性癫痫。我们的研究结果在各个研究中心和单个患者中重现，并且在不同的分析方法中具有稳健性。通过在ENIGMA癫痫的全球合作，我们提供了更深入的见解，形成常见癫痫的病理生理学的宏观特征。
Brain atrophy in human epilepsy syndromes is explainable by network architecture and strongest in hub regions. Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.
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影响因子：
5.7
作者：
Alexander-Bloch AF;Shou H;Liu S;Satterthwaite TD;Glahn DC;Shinohara RT;Vandekar SN;Raznahan A
通讯作者：
Raznahan A
影响因子：
3.4
作者：
Cohen, AS;Lin, DD;Coulter, DA
通讯作者：
Coulter, DA
影响因子：
4.7
作者：
Betzel, Richard F.;Griffa, Alessandra;Misic, Bratislav
通讯作者：
Misic, Bratislav
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI