Studies of a common idiotype PR4 in autoimmune rheumatic disease.

Studies of a common idiotype PR4 in autoimmune rheumatic disease.
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自身免疫性风湿病中常见独特型 PR4 的研究。

DOI:
10.1002/art.1780310903
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发表时间:
1988
影响因子:
--
通讯作者:
D. Isenberg
D. Isenberg
中科院分区:
--
文献类型:
--
作者:
W. Williams;Alimuddin Zumla;R. Behrens;M. Locniskar;A. Voller;K. McAdam;D. Isenberg

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A new common idiotype, designated PR4, is described. This idiotype was originally identified on a human hybridoma-derived monoclonal antibody from a patient with leprosy, which binds the major Mycobacterium leprae-derived antigen, phenolic glycolipid-1, poly(ADP)-ribose, DNA, and poly(dT). The PR4 idiotype was found in patients with systemic lupus erythematosus (SLE) (70%), rheumatoid arthritis (40%), and Sjögren's syndrome (15%). It was not, however, found in the spouses of the SLE patients or (unlike other lupus idiotypes) in their healthy first-degree relatives. Although no correlation between PR4 idiotype levels and disease activity in SLE was found, a subset of rheumatoid arthritis patients with high levels of the idiotype was identified.
来自麻风病患者的酚糖脂-I 人单克隆抗体,以及特异性抗独特型的生产。
DOI: --
发表时间: 1988
期刊: Immunology
影响因子: 6.4
作者:
Locniskar,M;Zumla,A;Mudd,DW;Isenberg,DA;Williams,W;McAdam,KP
通讯作者: McAdam,KP
DOI: 10.1172/jci112849
发表时间: 1987
期刊: The Journal of clinical investigation
影响因子: --
作者:
Mackworth-Young,C;Sabbaga,J;Schwartz,RS
通讯作者: Schwartz,RS
小鼠和人类抗 DNA 自身抗体表达共同的独特型。
DOI: --
发表时间: 1985
期刊: Immunology
影响因子: 6.4
作者:
Morgan,A;Isenberg,DA;Naparstek,Y;Rauch,J;Duggan,D;Khiroya,R;Staines,NA;Schattner,A
通讯作者: Schattner,A
狼疮血清和正常人血清含有具有相同独特型标记的抗DNA抗体。
DOI: --
发表时间: 1986
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Madaio,MP;Schattner,A;Shattner,M;Schwartz,RS
通讯作者: Schwartz,RS
人-人杂交瘤产生自身抗体。
DOI: 10.1172/jci110595
发表时间: 1982
期刊: The Journal of clinical investigation
影响因子: --
作者:
Shoenfeld,Y;Hsu-Lin,SC;Gabriels,JE;Silberstein,LE;Furie,BC;Furie,B;Stollar,BD;Schwartz,RS
通讯作者: Schwartz,RS