Risk of Colorectal Cancer After Solid Organ Transplantation in the United States.
Risk of Colorectal Cancer After Solid Organ Transplantation in the United States.
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DOI：
10.1111/ajt.13549
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Engels EA
中科院分区：
文献类型：
--
作者：
Safaeian M;Robbins HA;Berndt SI;Lynch CF;Fraumeni JF Jr;Engels EA
Solid organ transplant recipients have increased colorectal cancer (CRC) risk. We assessed CRC risk among transplant recipients and identified factors contributing to this association. The U.S. transplant registry was linked to 15 population-based cancer registries (1987–2010). We compared CRC risk in recipients to the general population using standardized incidence ratios (SIRs) and identified CRC risk factors using Poisson regression. Based on 790 CRCs among 224,098 transplants, recipients had elevated CRC risk (SIR=1.12, 95%CI:1.04–1.20). The increase was driven by an excess of proximal colon cancer (SIR=1.69, 95%CI:1.53–1.87), while distal colon cancer was not increased (SIR=0.93, 95%CI:0.80–1.07), and rectal cancer was reduced (SIR=0.64, 95%CI:0.54–0.76). In multivariate analyses, CRC was increased markedly in lung recipients with cystic fibrosis (incidence rate ratio [IRR]=12.3, 95%CI:6.94–21.9, vs. kidney recipients). Liver recipients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease also had elevated CRC risk (IRR=5.32, 95%CI:3.73–7.58). Maintenance therapy with cyclosporine and azathioprine was associated with proximal colon cancer (IRR=1.53; 95%CI:1.05–2.23). Incidence was not elevated in a subgroup of kidney recipients treated with tacrolimus and mycophenolate mofetil, pointing to the relevance of the identified risk factors. Transplant recipients have increased proximal colon cancer risk, likely related to underlying medical conditions (cystic fibrosis and PSC) and specific immunosuppressive regimens.
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美国实体器官移植后的 HPV 相关癌症。
DOI：
10.1111/ajt.12472
发表时间：
2013-12
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Madeleine MM;Finch JL;Lynch CF;Goodman MT;Engels EA
通讯作者：
Engels EA
影响因子：
8.9
作者：
Roithmaier, Sabine;Haydon, Andrew M.;Schwarz, Max A.
通讯作者：
Schwarz, Max A.
影响因子：
120.7
作者：
Engels, Eric A.;Pfeiffer, Ruth M.;Fraumeni, Joseph F., Jr.;Kasiske, Bertram L.;Israni, Ajay K.;Snyder, Jon J.;Wolfe, Robert A.;Goodrich, Nathan P.;Bayakly, A. Rana;Clarke, Christina A.;Copeland, Glenn;Finch, Jack L.;Fleissner, Mary Lou;Goodman, Marc T.;Kahn, Amy;Koch, Lori;Lynch, Charles F.;Madeleine, Margaret M.;Pawlish, Karen;Rao, Chandrika;Williams, Melanie A.;Castenson, David;Curry, Michael;Parsons, Ruth;Fant, Gregory;Lin, Monica
通讯作者：
Lin, Monica
影响因子：
8.8
作者：
Jiang, Y.;Villeneuve, P. J.;Mao, Y.
通讯作者：
Mao, Y.
影响因子：
10.3
作者：
Maisonneuve, Patrick;Marshall, Bruce C.;Lowenfels, Albert B.
通讯作者：
Lowenfels, Albert B.