Differential gene expression in migratory streams of cortical interneurons.
Differential gene expression in migratory streams of cortical interneurons.
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DOI：
10.1111/j.1460-9568.2011.07896.x
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Andrews WD
中科院分区：
文献类型：
--
作者：
Antypa M;Faux C;Eichele G;Parnavelas JG;Andrews WD
皮质中间神经元起源于腭下神经节隆起，并以明确的切向流迁移到皮质。在皮质生成开始时，两个迁移神经元的流是明显的：一个在前板水平（PPL）的表面，和一个更深的中间区水平（IZ）。目前，人们对调节中间神经元迁移的信号机制知之甚少，对可能参与其迁移流选择的分子几乎一无所知。在这里，我们进行了一个微阵列分析，比较在胚胎第13.5天在PPL和IZ迁移的细胞之间的基因表达的变化。这项分析确定了基因，其中许多是新的，在两个流之一上调。此外，聚合酶链反应，原位杂交实验和免疫组织化学显示，这些基因的表达在PPL或IZ内迁移的interneurons，这表明他们发挥了作用，在他们的迁移和选择的流。
Cortical interneurons originate in the ganglionic eminences of the subpallium and migrate into the cortex in well-defined tangential streams. At the start of corticogenesis, two streams of migrating neurons are evident: a superficial one at the level of the preplate (PPL), and a deeper one at the level of the intermediate zone (IZ). Currently, little is known about the signalling mechanisms that regulate interneuron migration, and almost nothing is known about the molecules that may be involved in their choice of migratory stream. Here, we performed a microarray analysis, comparing the changes in gene expression between cells migrating in the PPL and those migrating in the IZ at embryonic day 13.5. This analysis identified genes, many of them novel, that were upregulated in one of the two streams. Moreover, polymerase chain reaction, in situ hybridization experiments and immunohistochemistry showed the expression of these genes in interneurons migrating within the PPL or IZ, suggesting that they play a role in their migration and choice of stream.
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影响因子：
16.2
作者：
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通讯作者：
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影响因子：
4.6
作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Parnavelas, John G.