Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses.
Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses.
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DOI：
10.2217/fmb.10.102
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发表时间：
2010-09
影响因子：
3.1
通讯作者：
Coburn J
中科院分区：
文献类型：
--
作者：
Evangelista KV;Coburn J
钩端螺旋体病是世界上最广泛的人畜共患病，是一个新兴的公共卫生问题，特别是在发展中国家的大城市中心。钩端螺旋体属的几种致病性物种可引起广泛的临床表现，从轻微的流感样疾病到以导致死亡的多器官系统并发症为特征的严重疾病形式。然而，钩端螺旋体的致病机制在很大程度上是未知的。本文将讨论急性和慢性钩端螺旋体感染的动物模型，以及细菌遗传操作的最新进展，这些进展有助于鉴定致病相关的毒力因子，并评估其在钩端螺旋体病控制和预防中的潜在价值。
Leptospirosis, the most widespread zoonosis in the world, is an emerging public health problem, particularly in large urban centers of developing countries. Several pathogenic species of the genus Leptospira can cause a wide range of clinical manifestations, from a mild, flu-like illness to a severe disease form characterized by multiorgan system complications leading to death. However, the mechanisms of pathogenesis of Leptospira are largely unknown. This article will address the animal models of acute and chronic leptospire infections, and the recent developments in the genetic manipulation of the bacteria, which facilitate the identification of virulence factors involved in pathogenesis and the assessment of their potential values in the control and prevention of leptospirosis.
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影响因子：
3.1
作者：
Artiushin, S;Timoney, JF;Verma, A
通讯作者：
Verma, A
影响因子：
13.6
作者：
Cumberland, P;Everard, COR;Levett, PN
通讯作者：
Levett, PN
影响因子：
4.4
作者：
Chassin, Cecilia;Picardeau, Mathieu;Werts, Catherine
通讯作者：
Werts, Catherine
影响因子：
4.2
作者：
Atzingen MV;Barbosa AS;De Brito T;Vasconcellos SA;de Morais ZM;Lima DM;Abreu PA;Nascimento AL
通讯作者：
Nascimento AL
影响因子：
3.1
作者：
ADLER, B;FAINE, S
通讯作者：
FAINE, S