Replacement of the Gamma by the Delta variant in Brazil: Impact of lineage displacement on the ongoing pandemic.
Replacement of the Gamma by the Delta variant in Brazil: Impact of lineage displacement on the ongoing pandemic.
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DOI：
10.1093/ve/veac024
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发表时间：
2022
期刊：
影响因子：
5.3
通讯作者：
de Alcantara LCJ
中科院分区：
文献类型：
--
作者：
Giovanetti M;Fonseca V;Wilkinson E;Tegally H;San EJ;Althaus CL;Xavier J;Nanev Slavov S;Viala VL;Ranieri Jerônimo Lima A;Ribeiro G;Souza-Neto JA;Fukumasu H;Lehmann Coutinho L;Venancio da Cunha R;Freitas C;Campelo de A E Melo CF;Navegantes de Araújo W;Do Carmo Said RF;Almiron M;de Oliveira T;Coccuzzo Sampaio S;Elias MC;Covas DT;Holmes EC;Lourenço J;Kashima S;de Alcantara LCJ
巴西的2019冠状病毒病（COVID-19）疫情主要由伽马（P. 1）传播所驱动，伽马是一种于2021年1月初首次发现的当地出现的受关注变种（VOC）。据估计，2021年1月至6月期间报告的病例中有96%以上是由这种变异引起的，这与传播性和疾病严重程度增加、中和抗体减少、治疗或疫苗有效性降低以及诊断检测失败有关。在这里，我们表明，在主要来自美国的几次进口之后，Delta变体在2021年7月之后迅速取代了Gamma。然而，与其他国家的情况相反，德尔塔病毒的迅速传播并没有导致巴西报告的病例和死亡人数大幅增加。我们认为，这可能是由于相对成功的早期疫苗接种运动加上自然免疫获得后，以前感染伽马。我们的数据加强了Delta变异的传播性增加的报告，并考虑到最近发现的Omicron变异引起的日益关注，认为有必要加强国家层面的基因组监测，以快速检测可能威胁全球健康的其他VOC的出现和传播。
The coronavirus disease 2019 (COVID-19) epidemic in Brazil was driven mainly by the spread of Gamma (P.1), a locally emerged variant of concern (VOC) that was first detected in early January 2021. This variant was estimated to be responsible for more than 96 per cent of cases reported between January and June 2021, being associated with increased transmissibility and disease severity, a reduction in neutralization antibodies and effectiveness of treatments or vaccines, and diagnostic detection failure. Here we show that, following several importations predominantly from the USA, the Delta variant rapidly replaced Gamma after July 2021. However, in contrast to what was seen in other countries, the rapid spread of Delta did not lead to a large increase in the number of cases and deaths reported in Brazil. We suggest that this was likely due to the relatively successful early vaccination campaign coupled with natural immunity acquired following prior infection with Gamma. Our data reinforce reports of the increased transmissibility of the Delta variant and, considering the increasing concern due to the recently identified Omicron variant, argues for the necessity to strengthen genomic monitoring on a national level to quickly detect the emergence and spread of other VOCs that might threaten global health.
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DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
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DOI：
10.1093/bioinformatics/bty695
发表时间：
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期刊：
Bioinformatics (Oxford, England)
影响因子：
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作者：
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影响因子：
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影响因子：
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通讯作者：
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