Micropet imaging: in vivo biochemistry in small animals
Micropet imaging: in vivo biochemistry in small animals
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微型宠物成像：小动物体内生物化学
DOI：
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发表时间：
2005
影响因子：
3.3
通讯作者：
T. Ruth
中科院分区：
文献类型：
--
作者：
V. Sossi;T. Ruth
摘要：在过去的几年里，小动物生理功能成像所需的重大技术进步已经实现。专用的小动物PET扫描仪现在可以实现接近放射自显影方法的分辨率，同时仍然保持足够的检测灵敏度，以可靠地测量生物相关参数，如结合电位或速率常数。这些发展使研究人员能够探索人类疾病的体内啮齿动物模型。现在成像的未来在于多模态成像方法的发展，而未来几年的巨大挑战将是化学家开发更特异和反映所研究的功能条件的示踪剂，同时使化学合成相关仪器化。
Summary.Significant technological advancements required for imaging physiological function in small animals have been achieved in the last few years. Dedicated small animals PET scanners are now achieving resolutions that approach the one obtainable by autoradiographic methods, while still maintaining enough detection sensitivity to reliably measure biologically relevant parameters such as binding potentials or rate constants. Such developments have enabled researchers to explore in-vivo rodent models of human disease. The future in imaging now lies in the development of multi-modality imaging approaches, while the big challenge in the next few years will be for the chemists to develop tracers that are more specific and reflective of the functional condition under investigation, while miniaturizing the chemical synthesis related instrumentation.
影响因子：
2.5
作者：
S. Cherry;S. Gambhir
通讯作者：
S. Cherry;S. Gambhir
囊泡单胺转运蛋白不受多巴胺能药物治疗的调节。
影响因子：
5
作者：
VanderBorght,T;Kilbourn,M;Desmond,T;Kuhl,D;Frey,K
通讯作者：
Frey,K