Phenotype switching in melanoma: implications for progression and therapy.
Phenotype switching in melanoma: implications for progression and therapy.
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DOI：
10.3389/fonc.2015.00031
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发表时间：
2015
影响因子：
4.7
通讯作者：
Ferrao PT
中科院分区：
文献类型：
--
作者：
Li FZ;Dhillon AS;Anderson RL;McArthur G;Ferrao PT
上皮-间质转化（EMT）是上皮癌进展为转移性疾病的关键过程。在黑色素瘤中，已经报道了类似的表型转换过程，并且EMT相关基因已经涉及促进转移状态。本文综述了最近的研究信号通路和转录因子调节EMT样过程中的黑色素瘤的作用及其与患者的治疗反应，特别是对BRAF抑制，这是最初有效的，但有限的发展阻力和随后的进展。我们强调的研究涉及特定的作用，各种受体酪氨酸激酶（RTK）在推进黑色素瘤的进展，赋予增殖优势，并通过促进侵袭性表型和转移。我们还审查了目前的知识的机制，BRAF抑制和黑色素瘤表型转换在这一过程中的潜在作用。特别是，我们讨论了这些重要的新见解如何显着提高我们在治疗过程中预测黑色素瘤进展模式的能力，并可能促进未来联合治疗的合理发展。
Epithelial–mesenchymal transition (EMT) is a key process associated with the progression of epithelial cancers to metastatic disease. In melanoma, a similar process of phenotype switching has been reported and EMT-related genes have been implicated in promotion to a metastatic state. This review examines recent research on the role of signaling pathways and transcription factors regulating EMT-like processes in melanoma and their association with response to therapy in patients, especially response to BRAF inhibition, which is initially effective but limited by development of resistance and subsequent progression. We highlight studies implicating specific roles of various receptor tyrosine kinases (RTKs) in advancing melanoma progression by conferring a proliferative advantage and through promoting invasive phenotypes and metastasis. We also review the current knowledge of the mechanisms underlying resistance to BRAF inhibition and the potential role of melanoma phenotype switching in this process. In particular, we discuss how these important new insights may significantly enhance our ability to predict patterns of melanoma progression during treatment, and may facilitate rational development of combination therapies in the future.
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影响因子：
11.2
作者：
Alonso, Soledad R.;Tracey, Lorraine;Rodriguez-Peralto, Jose L.
通讯作者：
Rodriguez-Peralto, Jose L.
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
影响因子：
4
作者：
Bolós, V;Peinado, H;Cano, A
通讯作者：
Cano, A
影响因子：
3.3
作者：
CLARK, WH;ELDER, DE;VANHORN, M
通讯作者：
VANHORN, M
影响因子：
4.3
作者：
Eichhoff, Ossia M.;Weeraratna, Ashani;Hoek, Keith S.
通讯作者：
Hoek, Keith S.