Incident ischemic heart disease and recent occupational exposure to particulate matter in an aluminum cohort.
Incident ischemic heart disease and recent occupational exposure to particulate matter in an aluminum cohort.
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DOI：
10.1038/jes.2013.47
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发表时间：
2014-01
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
空气污染中的细颗粒物（PM2.5）主要来自燃烧源，被认为是心血管事件的重要危险因素，但对工作场所PM2.5暴露的研究很少。我们对11，966名美国铝工人进行了一项关于暴露于PM2.5和缺血性心脏病（IHD）发病率的前瞻性研究。IHD事件是从1998年至2008年的医疗索赔数据中确定的。针对近期暴露（去年内）和累积暴露制定了定量指标;然而，我们强调在随访之前缺乏可解释的工作历史的情况下的近期暴露。IHD与最近的PM2.5总体相关。在仅限于最近暴露的分析中，以最高置信度估计，第二四分位数的风险比（HR）增加至1.78（95%CI：1.02，3.11），并保持升高。当分析是分层的工作过程中，人力资源单调上升到1.5在冶炼厂和制造设施，虽然接触几乎是一个数量级更高的冶炼厂。不同的暴露反应可能是由于暴露成分或健康工人幸存者效应的差异。这些结果与空气污染和香烟烟雾文献一致;最近在工作场所暴露于PM2.5似乎会增加IHD发病率的风险。
Fine particulate matter (PM2.5) in air pollution, primarily from combustion sources, is recognized as an important risk factor for cardiovascular events but studies of workplace PM2.5 exposure are rare. We conducted a prospective study of exposure to PM2.5 and incidence of ischemic heart disease (IHD) in a cohort of 11,966 US aluminum workers. Incident IHD was identified from medical claims data from 1998 to 2008. Quantitative metrics were developed for recent exposure (within the last year) and cumulative exposure; however, we emphasize recent exposure in the absence of interpretable work histories prior to follow-up. IHD was modestly associated with recent PM2.5 overall. In analysis restricted to recent exposures estimated with the highest confidence, the hazard ratio (HR) increased to 1.78 (95%CI: 1.02, 3.11) in the second quartile and remained elevated. When the analysis was stratified by work process, the HR rose monotonically to 1.5 in both smelter and fabrication facilities, though exposure was almost an order of magnitude higher in smelters. The differential exposure-response may be due to differences in exposure composition or healthy worker survivor effect. These results are consistent with the air pollution and cigarette smoke literature; recent exposure to PM2.5 in the workplace appears to increase the risk of IHD incidence.
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影响因子：
11.4
作者：
LEADERER, BP;HAMMOND, SK
通讯作者：
HAMMOND, SK
影响因子：
3.5
作者：
Costello, Sadie;Garcia, Erika;Eisen, Ellen A.
通讯作者：
Eisen, Ellen A.
影响因子：
5.4
作者：
Chevrier, Jonathan;Picciotto, Sally;Eisen, Ellen A.
通讯作者：
Eisen, Ellen A.
影响因子：
5.4
作者：
Burstyn, I;Kromhout, H;Boffetta, P
通讯作者：
Boffetta, P
影响因子：
2.1
作者：
Ghio, AJ;Hall, A;Devlin, RB
通讯作者：
Devlin, RB