Effects of alternating current frequency and permeation enhancers upon human epidermal membrane.
Effects of alternating current frequency and permeation enhancers upon human epidermal membrane.
复制标题
交替的电流频率和渗透增强子对人表皮膜的影响。
DOI：
10.1016/j.ijpharm.2008.12.036
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发表时间：
2009-05-08
影响因子：
5.8
通讯作者：
Li, S. Kevin
中科院分区：
文献类型：
--
作者：
Xu, Qingfang;Kochambilli, Rajan P.;Song, Yang;Hao, Jinsong;Higuchi, William I.;Li, S. Kevin
关键词：
Previous studies have demonstrated the ability of AC iontophoresis to control skin resistance in different transdermal iontophoresis applications. The objectives of the present study were to (a) identify the alternating current (AC) frequency for the optimization of AC pore induction of human epidermal membrane (HEM) and (b) determine the effects of chemical permeation enhancers upon the extent of pore induction under AC conditions. Experiments with a synthetic membrane system were first conducted as the control. In these synthetic membrane experiments, the electrical resistance of the membrane remained essentially constant, suggesting constant electromobility of the background electrolyte ions under the AC conditions studied. In the HEM experiments, the electrical resistance data showed that higher applied voltages were required to induce the same extent of pore induction in HEM at AC frequency of 1 kHz compared with those at 30 Hz. Even higher voltages were needed at AC frequencies of 10 kHz and higher. AC frequency also influenced the recovery of HEM electrical resistance after AC iontophoresis application. An optimal AC frequency region for effective pore induction and least sensation was proposed. Permeation enhancers were shown to enhance pore induction in HEM during AC iontophoresis. The enhancers reversibly reduced the AC voltage required to sustain a constant state of pore induction in HEM during AC iontophoresis, consistent with the mechanism of lipid lamellae electroporation in the stratum corneum.
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影响因子：
5.8
作者：
PECK, KD;GHANEM, AH;SRINIVASAN, V
通讯作者：
SRINIVASAN, V
影响因子：
3.8
作者：
PECK, KD;GHANEM, AH;HIGUCHI, WI
通讯作者：
HIGUCHI, WI
DOI：
10.1016/0005-2736(88)90202-7
发表时间：
1988-05-24
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
GLASER, RW;LEIKIN, SL;SOKIRKO, AI
通讯作者：
SOKIRKO, AI
影响因子：
3.8
作者：
MILLER, LL;KOLASKIE, CJ;RIVIER, J
通讯作者：
RIVIER, J
影响因子：
5.8
作者：
Nakamura, K;Katagai, K;Yamamoto, K
通讯作者：
Yamamoto, K