Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents.
Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents.
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抗肿瘤剂281。取代4-氨基-7,8,9,9,10-四氢-2H-Benzo [H] Chromen-2-nos-nosoge（ATBO）的设计，合成和生物学活性（ATBO）作为有效的体外抗癌药物。
DOI：
10.1016/j.bmcl.2010.10.074
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发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Lee, Kuo-Hsiung
中科院分区：
文献类型：
--
作者：
Dong, Yizhou;Nakagawa-Goto, Kyoko;Lai, Chin-Yu;Morris-Natschke, Susan L.;Bastow, Kenneth F.;Lee, Kuo-Hsiung
关键词：
In our exploration of new biologically active chemical entities, we designed and synthesized a novel class of antitumor agents, substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (ATBO) analogs. We evaluated their cytotoxic activity against seven human tumor cell lines from different tissues, and established preliminary structure-activity relationships (SAR). All analogues, except 8, 9, and 25-27, displayed potent tumor cell growth inhibitory activity. Especially, compounds 15 and 33 with a 4-methoxyphenyl group at position C-4 were extremely potent with ED50 values of 0.008-0.064 μM and 0.035-0.32 μM, respectively. Compound 15 was the most potent analog compared with structurally related neo-tanshinlactone (e.g., 1) and 4-amino-2H-benzo[h]chromen-2-one (ABO, e.g., 4) analogs, and thus merits further exploration as an anti-cancer drug candidate.
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影响因子：
7.3
作者：
Dong Y;Shi Q;Liu YN;Wang X;Bastow KF;Lee KH
通讯作者：
Lee KH
影响因子：
15
作者：
Kim, Dae-Shik;Dong, Cheng-Guo;Kishi, Yoshito
通讯作者：
Kishi, Yoshito
影响因子：
2.7
作者：
Dong, Yizhou;Nakagawa-Goto, Kyoko;Lai, Chin-Yu;Morris-Natschke, Susan L.;Bastow, Kenneth F.;Lee, Kuo-Hsiung
通讯作者：
Lee, Kuo-Hsiung
影响因子：
2.1
作者：
Alberola, A;Alvaro, R;Sañudo, MC
通讯作者：
Sañudo, MC
DOI：
10.1016/s0014-827x(03)00160-5
发表时间：
2003-11-01
期刊：
Farmaco (Lausanne)
影响因子：
--
作者：
Di Braccio, Mario;Grossi, Giancarlo;Bordin, Franco
通讯作者：
Bordin, Franco