Association between maternal breastfeeding and risk of systemic neoplasms of offspring.
Association between maternal breastfeeding and risk of systemic neoplasms of offspring.
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DOI：
10.1186/s13052-022-01292-9
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发表时间：
2022-06-16
影响因子：
3.6
通讯作者：
Zhang, Zhi-Jun
中科院分区：
文献类型：
--
作者：
Gong, Qin-Qin;Quan, Dan-Dan;Guo, Chong;Zhang, Chao;Zhang, Zhi-Jun
关键词：
母乳喂养可以通过刺激免疫系统来预防儿童癌症。对以下数据库（包括 PubMed、Embase 和 Cochrane Library）的检索时间从开始到 2021 年 1 月 10 日。以剂量依赖性方式，母乳喂养与儿童癌症发病率之间存在统计学上显着的负相关关系。没有证据表明母乳喂养与儿童骨骼、生殖或感觉系统癌症呈负相关。然而，母乳喂养与血液恶性肿瘤以及神经和泌尿系统癌症的发病率呈负相关。在血液系统恶性肿瘤中，这种关系对于急性淋巴细胞白血病 (ALL) 和急性髓系白血病 (AML) 显着，但对于急性非淋巴细胞白血病 (ANLL)、霍奇金淋巴瘤 (HL) 或非 HL 则不显着。证据表明，母乳喂养在预防选择性儿童癌症生长方面具有潜在的保护作用，特别是对于 ALL、AML、神经和泌尿系统癌症。这项研究建议尽可能延长母乳喂养时间或维持至少 6 个月，以预防选择性儿童癌症的生长。在线版本包含可在 10.1186/s13052-022-01292-9 获取的补充材料。
Breastfeeding might prevent childhood cancer by stimulating the immune system. The following databases, including PubMed, Embase, and Cochrane Library, were searched from inception to January 10, 2021. In dose-dependent manner, there was a statistically significant inverse association between any breastfeeding and the incidence of childhood cancer. There was no evidence that breastfeeding was inversely related to childhood cancer of the skeletal, reproductive, or sensory systems. However, breastfeeding was inversely associated with the incidence of hematological malignancies and cancers of the nervous and urinary systems. Among hematological malignancies, the relationship was significant for acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML), but not for acute non-lymphocytic leukemia (ANLL), Hodgkin’s lymphoma (HL), or non-HL. The evidences demonstrated that breastfeeding have a potential protective role in preventing selective childhood cancer growth, especially for ALL, AML, cancer of nervous and urinary systems. This study recommended that breastfeeding be extended for as long as possible or maintained for at least 6 months to prevent selective childhood cancer growth. The online version contains supplementary material available at 10.1186/s13052-022-01292-9.
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影响因子：
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作者：
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作者：
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