Improving pharmaceutical aerosol delivery during noninvasive ventilation: effects of streamlined components.
Improving pharmaceutical aerosol delivery during noninvasive ventilation: effects of streamlined components.
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DOI：
10.1007/s10439-013-0759-9
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发表时间：
2013-06
影响因子：
3.8
通讯作者：
Hindle, Michael
中科院分区：
文献类型：
--
作者：
Longest, P. Worth;Golshahi, Laleh;Hindle, Michael
关键词：
众所周知，无创呼吸机(NIV)的雾化吸入效率较低(~10%)，与雾化治疗效果不佳有关。这项研究的目的是证明在成人鼻腔高流量治疗期间使用网状雾化器提供常规尺寸的气雾剂时，使用流线型方法重新设计通风回路组件以改善气雾剂输送的好处。通气路由加湿器、网状雾化器、混合T形接头(90°角)、10 mm管路和鼻插管接口组成。通过体外实验和计算流体力学分析，评估了现有组件和新提出的流线型T形连接器和套管在30和45LPM的流速下的沉积损失。流线型设计将T型连接器中的沉积减少了4倍。在鼻插管中，流线型设计将沉积损失减少了1.25-2.0倍。在流线型设计下，在30LPM时，常规尺寸的气雾剂的最高排放剂量为>；40%。流线型几何结构提供了一种有效的方法，通过NIV系统的组件显著改善气雾剂的输送。这种给药效率的提高对于治疗窗口窄、成本增加或给药时间长的新型吸入药物很重要。
Aerosol delivery efficiency during noninvasive ventilation (NIV) is known to be low (~10%) and is associated with poor outcomes of aerosol therapy. The objective of this study was to demonstrate the benefit of redesigning ventilation circuit components using a streamlining approach to improve aerosol delivery during nasal high flow therapy in adults with a conventional-sized aerosol from a mesh nebulizer. The ventilation circuit consisted of a humidifier, mesh nebulizer, mixing T-connector (with 90° angle), 10 mm tubing, and nasal cannula interface. In vitro experiments and computational fluid dynamics analyses were used to evaluate depositional losses in a system of existing components and a newly proposed streamlined T-connector and cannula at flow rates of 30 and 45 LPM. Streamlined designs reduced deposition in the T-connector by a factor of 4. In the nasal cannula, the streamlined designs reduced depositional losses by factors of 1.25–2.0. With the streamlined designs, the highest emitted dose achieved was >40% for a conventional-sized aerosol at 30 LPM. Streamlined geometries offer an effective method to significantly improve the delivery of aerosols through components of NIV systems. This increase in delivery efficiency is important for new inhaled medications with narrow therapeutic windows, increased costs, or long delivery times.
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影响因子：
5
作者：
CHENG, YS;WANG, CS
通讯作者：
WANG, CS
DOI：
10.1089/jamp.2008.0739
发表时间：
2009-09-01
影响因子：
3.4
作者：
Longest, P. Worth;Hindle, Michael
通讯作者：
Hindle, Michael
DOI：
10.1089/jamp.2008.0708
发表时间：
2009-06-01
影响因子：
3.4
作者：
Longest, P. Worth;Hindle, Michael
通讯作者：
Hindle, Michael
影响因子：
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作者：
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通讯作者：
Vinchurkar, Samir
影响因子：
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作者：
Longest, PW;Kleinstreuer, C;Buchanan, JR
通讯作者：
Buchanan, JR