Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma.
Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma.
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DOI：
10.3390/ijms18010149
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发表时间：
2017-01-13
影响因子：
5.6
通讯作者：
Fabris L
中科院分区：
文献类型：
--
作者：
Cadamuro M;Brivio S;Spirli C;Joplin RE;Strazzabosco M;Fabris L
对常规化疗药物的耐药性是胆管癌的典型特征，它阻碍了通常用于对抗人类恶性肿瘤的治疗武器的疗效。肿瘤性胆管细胞的化疗耐药机制包括逃避肿瘤微环境中释放的自分泌和旁分泌信号介导的药物诱导的凋亡。在这里，最近的证据，化疗耐药的分子机制进行审查，以及发达的化疗耐药性和激活的癌症干细胞室之间的关联。它的结论是，更好地了解细胞凋亡信号和促进细胞存活之间的复杂的相互作用代表了积极调查的潜在生产领域，最终目的是鼓励未来的研究，以揭示新的，有效的策略，能够克服目前的治疗限制。
Resistance to conventional chemotherapeutic agents, a typical feature of cholangiocarcinoma, prevents the efficacy of the therapeutic arsenal usually used to combat malignancy in humans. Mechanisms of chemoresistance by neoplastic cholangiocytes include evasion of drug-induced apoptosis mediated by autocrine and paracrine cues released in the tumor microenvironment. Here, recent evidence regarding molecular mechanisms of chemoresistance is reviewed, as well as associations between well-developed chemoresistance and activation of the cancer stem cell compartment. It is concluded that improved understanding of the complex interplay between apoptosis signaling and the promotion of cell survival represent potentially productive areas for active investigation, with the ultimate aim of encouraging future studies to unveil new, effective strategies able to overcome current limitations on treatment.
影响因子：
8.8
作者：
Paradiso A;Simone G;Lena MD;Leone B;Vallejo C;Lacava J;Dellapasqua S;Daidone MG;Costa A
通讯作者：
Costa A