Deleterious effects of mycotoxin combinations involving ochratoxin A.
Deleterious effects of mycotoxin combinations involving ochratoxin A.
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DOI：
10.3390/toxins5111965
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发表时间：
2013-11-01
期刊：
影响因子：
4.2
通讯作者：
Peraica M
中科院分区：
文献类型：
--
作者：
Klarić MS;Rašić D;Peraica M
赭曲霉毒素A （OTA）是一种具有致癌性质的肾毒性真菌毒素。在世界各地的各种食品中都检测到它的存在，但在地方性肾病（EN）地区，其频率和浓度明显更高。尽管食物经常被一种以上的霉菌毒素污染，但早期的研究只关注OTA的发生和毒理学。只有少数调查显示，OTA与真菌毒素（柑桔霉素- cit、青霉酸、伏马菌素B1-FB1、黄曲霉毒素- af）共同发生在食品中，这些真菌毒素具有肾毒性、致癌性或促进致癌性。本文综述了有关OTA及其与上述真菌毒素在食品中共存的研究结果，以及它们联合毒性的实验数据。在实验模型中，大多数涉及OTA的经测试霉菌毒素混合物产生了相加或协同效应，表明这些组合构成了重大的健康危害。应特别注意含有致癌和促癌真菌毒素的混合物。
Ochratoxin A (OTA) is a nephrotoxic mycotoxin with carcinogenic properties. Its presence was detected in various foodstuffs all over the world but with significantly higher frequency and concentrations in areas with endemic nephropathy (EN). Even though food is often contaminated with more than one mycotoxin, earlier studies focused on the occurrence and toxicology of only OTA. Only a limited number of surveys showed that OTA co-occurs in food with mycotoxins (citrinin-CIT, penicilic acid, fumonisin B1-FB1, aflatoxins-AF) which exert nephrotoxic, carcinogenic or carcinogen-promoting activity. This review summarises the findings on OTA and its co-occurrence with the mentioned mycotoxins in food as well as experimental data on their combined toxicity. Most of the tested mycotoxin mixtures involving OTA produced additive or synergistic effects in experimental models suggesting that these combinations represent a significant health hazard. Special attention should be given to mixtures that include carcinogenic and cancer-promoting mycotoxins.
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