Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.
Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.
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家族性乳腺癌与染色体 17q21 的连锁可能不仅限于早发性疾病。
DOI：
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发表时间：
1992
影响因子：
9.8
通讯作者：
Françoise Clerget‐Darpoux
中科院分区：
文献类型：
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作者：
Patricia Margaritte;Catherine Bonaïti;Mary Claire King;Françoise Clerget‐Darpoux
家族性乳腺癌和卵巢癌之间的联系和17q21染色体标记的Lod评分在年龄较小的家族中比在年龄较大的家族中更频繁地呈阳性，这表明这种联系仅限于早发性疾病。然而，对于晚发病例，散发而非遗传性疾病的相对概率高于先前的建议。如果纠正了这一点，那么晚发家庭提供的信息就少得多；基于发病年龄的连锁异质性不再显著；对于作为一个整体的家庭样本来说，在重组分数上的联系是显著的，因为它被证明是接近正确的地方。遗传乳腺癌的基因可能不止一个，但异质性可能不是由于发病年龄。
Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease. However, for late-onset cases, the relative probability of sporadic rather than inherited disease is higher than previously suggested. If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local. There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset.
影响因子：
9.8
作者：
E. Claus;N. Risch;W. Thompson
通讯作者：
E. Claus;N. Risch;W. Thompson
影响因子：
9.8
作者：
Jeff Hall;L. Friedman;C. Guenther;Ming K. Lee;J. Weber;D. Black;M. King
通讯作者：
Jeff Hall;L. Friedman;C. Guenther;Ming K. Lee;J. Weber;D. Black;M. King
影响因子：
56.9
作者：
HALL, JM;LEE, MK;KING, MC
通讯作者：
KING, MC