Type Strains of Entomopathogenic Nematode-Symbiotic Bacterium Species, Xenorhabdus szentirmaii (EMC) and X. budapestensis (EMA), Are Exceptional Sources of Non-Ribosomal Templated, Large-Target-Spectral, Thermotolerant-Antimicrobial Peptides (by Both), and Iodinin (by EMC).
Type Strains of Entomopathogenic Nematode-Symbiotic Bacterium Species, Xenorhabdus szentirmaii (EMC) and X. budapestensis (EMA), Are Exceptional Sources of Non-Ribosomal Templated, Large-Target-Spectral, Thermotolerant-Antimicrobial Peptides (by Both), and Iodinin (by EMC).
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昆虫病原线虫共生菌种的典型菌株，森氏致病杆菌 (EMC) 和布达佩斯致病杆菌 (EMA)，是非核糖体模板化、大靶标光谱、耐热抗菌肽（两者均提供）和碘宁的特殊来源。通过 EMC）。
DOI：
10.3390/pathogens11030342
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发表时间：
2022-03-11
期刊：
影响因子：
--
通讯作者：
Vellai T
中科院分区：
文献类型：
--
作者：
Fodor A;Gualtieri M;Zeller M;Tarasco E;Klein MG;Fodor AM;Haynes L;Lengyel K;Forst SA;Furgani GM;Karaffa L;Vellai T
抗生素多药耐药性（MDR）是一个全球性的挑战，不仅对公共卫生，而且对可持续农业。用于人类的抗生素应排除用于兽医或农业环境。应用由土生生物产生的抗菌肽（AMP）分子来保护（土生）植物，似乎是一个更好的选择。由昆虫病原线虫/细菌（EPN/EPB）共生体的原核伴侣产生的肽-抗微生物剂的天然作用是维持半复苏感染性道尔幼虫（IJ）EPN肠道中EPB的单菌条件。它们使病原生物群条件在多异生（土壤、被征服的昆虫尸体）小生境中的EPN/EPB复合物保持平衡。szentirmaii DSM 16338（T）（EMC）和X. budapestensis DSM 16342（T）（EMA）分别是EPN种稀有斯氏线虫（Steinernema rarum）和S.双角藻我们在15年前发现并描述了这两种情况。对EMC基因组草图进行功能注释，发现71个编码非核糖体肽脱氢酶和聚酮脱氢酶的基因。在EMA中发现了大空间的黄杆菌AMP（fabclavine），并且在EMC中发现了其生物合成途径。由EMA和EMC产生的AMP是用于控制MDR原核和真核病原体（细菌、卵菌、真菌、原生动物）的有希望的候选物。EMC以水溶性形式将大量碘（1，6-二羟基吩嗪5，10-二氧化物）释放到介质中，在那里它冷凝形成壮观的水不溶性宏观晶体。本综述评估了国际研究对EMA和EMC的科学影响。
Antimicrobial multidrug resistance (MDR) is a global challenge, not only for public health, but also for sustainable agriculture. Antibiotics used in humans should be ruled out for use in veterinary or agricultural settings. Applying antimicrobial peptide (AMP) molecules, produced by soil-born organisms for protecting (soil-born) plants, seems a preferable alternative. The natural role of peptide-antimicrobials, produced by the prokaryotic partner of entomopathogenic-nematode/bacterium (EPN/EPB) symbiotic associations, is to sustain monoxenic conditions for the EPB in the gut of the semi-anabiotic infective dauer juvenile (IJ) EPN. They keep pathobiome conditions balanced for the EPN/EPB complex in polyxenic (soil, vanquished insect cadaver) niches. Xenorhabdus szentirmaii DSM16338(T) (EMC), and X. budapestensis DSM16342(T) (EMA), are the respective natural symbionts of EPN species Steinernema rarum and S. bicornutum. We identified and characterized both of these 15 years ago. The functional annotation of the draft genome of EMC revealed 71 genes encoding non-ribosomal peptide synthases, and polyketide synthases. The large spatial Xenorhabdus AMP (fabclavine), was discovered in EMA, and its biosynthetic pathway in EMC. The AMPs produced by EMA and EMC are promising candidates for controlling MDR prokaryotic and eukaryotic pathogens (bacteria, oomycetes, fungi, protozoa). EMC releases large quantity of iodinin (1,6-dihydroxyphenazine 5,10-dioxide) in a water-soluble form into the media, where it condenses to form spectacular water-insoluble, macroscopic crystals. This review evaluates the scientific impact of international research on EMA and EMC.
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影响因子：
2.1
作者：
AKHURST, RJ
通讯作者：
AKHURST, RJ
影响因子：
11.8
作者：
Boucher, Helen W.;Talbot, George H.;Bartlett, John
通讯作者：
Bartlett, John
影响因子：
4
作者：
Boeszoermenyi, E.;Ersek, T.;Taylor, R. A. J.
通讯作者：
Taylor, R. A. J.
DOI：
10.1080/14756366.2017.1421638
发表时间：
2018-12
影响因子：
5.6
作者：
Prandina A;Herfindal L;Radix S;Rongved P;Døskeland SO;Le Borgne M;Perret F
通讯作者：
Perret F
影响因子：
2.7
作者：
CASSADA, RC;RUSSELL, RL
通讯作者：
RUSSELL, RL