Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation.
Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation.
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DOI：
10.1007/s00592-017-1097-4
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发表时间：
2018-04
影响因子：
3.8
通讯作者：
Brizzi MF
中科院分区：
文献类型：
--
作者：
Bo S;Togliatto G;Gambino R;Ponzo V;Lombardo G;Rosato R;Cassader M;Brizzi MF
2型糖尿病（T2 DM）中SIRT-1的下调与氧化应激的表观遗传标志物有关。本文旨在评估SIRT-1表达的增加是否影响随机选择接受白藜芦醇（40 mg或500 mg）或安慰剂治疗6个月的T2 DM患者中组蛋白3 56赖氨酸残基（H3 K56 ac）的乙酰化。主要结果是SIRT-1表达变化引起的H3 K56 ac水平的变化，次要结果是SIRT-1水平、抗氧化标记物（TAS）和代谢变量之间相关性的证据。在基线时，SIRT-1三分位数之间的外周血单核细胞H3 K56 ac值没有差异。在试验结束时，接受500 mg白藜芦醇的患者的SIRT-1水平显著较高。在随访时，将患者分为delta（试验结束减去基线）SIRT-1值的三分位数。在最高三分位数中发现H3 K56 ac和体脂百分比显着降低，TAS水平升高。多元逻辑回归模型显示，最高Δ SIRT-1三分位数与H3 K56 ac（OR = 0.66; 95%CI 0.44-0.99）、TAS（OR = 1.01; 95%CI 1.00-1.02）和体脂百分比（OR = 0.75; 95%CI 0.58-0.96）的变化呈负相关。 我们提供了T2 DM中H3 K56 ac和SIRT-1相关性的新知识。这些数据表明，增强SIRT-1表达/活化可能会影响这些患者的氧化还原稳态。ClinicalTrials.gov标识符NCT 02244879。
Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive either resveratrol (40 mg or 500 mg) or a placebo for 6 months. The primary outcome is changes in the H3K56ac level by variation in SIRT-1 expression and the secondary outcome is the evidence of association between SIRT-1 level, antioxidant markers (TAS), and metabolic variables. At baseline, peripheral blood mononuclear cell H3K56ac values among the SIRT-1 tertiles did not differ. At trial end, SIRT-1 levels were significantly higher in patients receiving 500 mg resveratrol. At follow-up, patients were divided into tertiles of delta (trial end minus baseline) SIRT-1 value. Significant reductions in H3K56ac and body fat percentage were found in the highest tertile as were increased TAS levels. A multiple logistic regression model showed that the highest delta SIRT-1 tertile was inversely associated with variations in H3K56ac (OR = 0.66; 95% CI 0.44–0.99), TAS (OR = 1.01; 95% CI 1.00–1.02), and body fat percentage (OR = 0.75; 95% CI 0.58–0.96). We provide new knowledge on H3K56ac and SIRT-1 association in T2DM. These data suggest that boosting SIRT-1 expression/activation may impact redox homeostasis in these patients. ClinicalTrials.gov Identifier NCT02244879.
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影响因子：
7.7
作者：
Paneni F;Volpe M;Lüscher TF;Cosentino F
通讯作者：
Cosentino F
在临床实践中降低脂质的营养液：国际脂质专家小组的定位论文。
DOI：
10.5114/aoms.2017.69326
发表时间：
2017-08
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Cicero AFG;Colletti A;Bajraktari G;Descamps O;Djuric DM;Ezhov M;Fras Z;Katsiki N;Langlois M;Latkovskis G;Panagiotakos DB;Paragh G;Mikhailidis DP;Mitchenko O;Paulweber B;Pella D;Pitsavos C;Reiner Ž;Ray KK;Rizzo M;Sahebkar A;Serban MC;Sperling LS;Toth PP;Vinereanu D;Vrablík M;Wong ND;Banach M
通讯作者：
Banach M
偏斜的表观遗传学：糖尿病并发症的替代治疗选择。
影响因子：
4.3
作者：
Togliatto G;Dentelli P;Brizzi MF
通讯作者：
Brizzi MF
影响因子：
3.8
作者：
Song SB;Jang SY;Kang HT;Wei B;Jeoun UW;Yoon GS;Hwang ES
通讯作者：
Hwang ES
影响因子：
3.7
作者：
Lo KA;Bauchmann MK;Baumann AP;Donahue CJ;Thiede MA;Hayes LS;des Etages SA;Fraenkel E
通讯作者：
Fraenkel E