Research gaps for three main tropical diseases in the People's Republic of China.
Research gaps for three main tropical diseases in the People's Republic of China.
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DOI：
10.1186/2049-9957-2-15
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发表时间：
2013-07-29
影响因子：
8.1
通讯作者：
Zhang HB
中科院分区：
文献类型：
--
作者：
Zheng Q;Vanderslott S;Jiang B;Xu LL;Liu CS;Huo LL;Duan LP;Wu NB;Li SZ;Xia ZG;Wu WP;Hu W;Zhang HB
这篇范围综述分析了三种疾病：日本血吸虫病、疟疾和包虫病的研究差距。基于中华人民共和国中国的现有数据，我们强调了控制能力与患病率水平之间的差距，以及在国家控制方案的不同阶段诊断/药物开发与人口治疗需求之间的差距。在审查了848项原始研究的文献并咨询了该领域的专家后，发现了以下差距。首先，疟疾研究方面的差距包括：(1)公共社区缺乏积极的检测，没有适当的技术来评估消灭；(2)缺乏对无症状患者的敏感诊断工具；(3)缺乏安全的大规模给药药物。其次，血吸虫病研究的空白包括：(1)血吸虫病综合防治策略实施的政策不一致；(2)缺乏有效的钉螺防治工具。(3)缺乏对大量人口样本更敏感和更便宜的诊断测试；(4)除吡喹酮外，缺乏新药。第三，包虫病研究方面的空白包括：(1)现场流行病学研究能力低；(2)疫区缺乏改善卫生条件的研究；(3)缺乏早期诊断的敏感性测试；(4)缺乏更有效的短期治疗药物。我们相信，如果在短时间内缩小所有研究空白，这三种疾病最终在内地中国是可以消除的。
This scoping review analyzes the research gaps of three diseases: schistosomiasis japonica, malaria and echinococcosis. Based on available data in the P.R. China, we highlight the gaps between control capacity and prevalence levels, and between diagnostic/drug development and population need for treatment at different stages of the national control programme. After reviewing the literature from 848 original studies and consultations with experts in the field, the gaps were identified as follows. Firstly, the malaria research gaps include (i) deficiency of active testing in the public community and no appropriate technique to evaluate elimination, (ii) lack of sensitive diagnostic tools for asymptomatic patients, (iii) lack of safe drugs for mass administration. Secondly, gaps in research of schistosomiasis include (i) incongruent policy in the implementation of integrated control strategy for schistosomiasis, (ii) lack of effective tools for Oncomelania sp. snail control, (iii) lack of a more sensitive and cheaper diagnostic test for large population samples, (iv) lack of new drugs in addition to praziquantel. Thirdly, gaps in research of echinococcosis include (i) low capacity in field epidemiology studies, (ii) lack of sanitation improvement studies in epidemic areas, (iii) lack of a sensitivity test for early diagnosis, (iv) lack of more effective drugs for short-term treatment. We believe these three diseases can eventually be eliminated in mainland China if all the research gaps are abridged in a short period of time.
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影响因子：
5.5
作者：
Breman, Joel G.;Brandling-Bennett, A. David
通讯作者：
Brandling-Bennett, A. David
中华人民共和国寄生虫研究的前沿：感染，诊断，保护和监视。
影响因子：
3.2
作者：
Chen JH;Wang H;Chen JX;Bergquist R;Tanner M;Utzinger J;Zhou XN
通讯作者：
Zhou XN
影响因子：
168.9
作者：
Feachem, Richard G. A.;Phillips, Allison A.;Hwang, Jimee;Cotter, Chris;Wielgosz, Benjamin;Greenwood, Brian M.;Sabot, Oliver;Henry Rodriguez, Mario;Abeyasinghe, Rabindra R.;Ghebreyesus, Tedros Adhanom;Snow, Robert W.
通讯作者：
Snow, Robert W.
DOI：
10.1128/cdli.8.5.891-894.2001
发表时间：
2001-09-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Adak, T;Valecha, N;Sharma, VP
通讯作者：
Sharma, VP
影响因子：
8.1
作者：
Collins C;Xu J;Tang S
通讯作者：
Tang S