Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men.
Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men.
复制标题
β2-肾上腺素能受体基因的 Gln27Glu 和 Arg16Gly 多态性与日本男性的肥胖无关。
DOI：
--
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
K. Kobayashi
中科院分区：
文献类型：
--
作者：
T. Hayakawa;Y. Nagai;Toshio Kahara;H. Yamashita;T. Takamura;T. Abe;G. Nomura;K. Kobayashi
β -肾上腺素能受体（β - 2ar）、β - 3ar或解偶联蛋白1 （UCP1）可能在肥胖中起致病作用。在瑞典高加索人中，beta2AR基因密码子27 （Gln27Glu）多态性被证明与肥胖有关，但密码子16 （Arg16Gly）多态性未被证明与肥胖有关。因此，我们在210名日本男性中调查了这些多态性是否与肥胖有关。Gln27Glu和Arg16Gly多态性频率分别为0.05和0.48，与肥胖无关。Gln27Glu和Arg16Gly多态性之间存在强烈的连锁不平衡，但对临床或代谢特征没有明显的加性影响。我们的研究结果表明，β 2ar基因的Gln27Glu和Arg16Gly多态性并不是导致日本男性肥胖的主要因素。
The beta2-adrenergic receptor (beta2AR), beta3AR, or uncoupling protein 1 (UCP1) may play a pathogenic role in obesity. In Swedish Caucasians, a polymorphism at codon 27 (Gln27Glu) of the beta2AR gene was shown to be associated with obesity, but no such association was shown for a polymorphism of codon 16 (Arg16Gly). Thus, we investigated whether these polymorphisms contribute to obesity in 210 Japanese men. The frequencies of the Gln27Glu and Arg16Gly polymorphisms were 0.05 and 0.48, respectively, and there was no association with obesity. A strong linkage disequilibrium between the Gln27Glu and Arg16Gly polymorphisms was shown, but there was no apparent additive effect on the clinical or metabolic characteristics. Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
DOI：
--
发表时间：
1994-08
期刊：
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
影响因子：
--
作者：
J. Oppert;M. Vohl;M. Chagnon;F. Dionne;A. Cassard‐Doulcier;D. Ricquier;L. Pérusse;C. Bouchard
通讯作者：
J. Oppert;M. Vohl;M. Chagnon;F. Dionne;A. Cassard‐Doulcier;D. Ricquier;L. Pérusse;C. Bouchard
影响因子：
158.5
作者：
WALSTON, J;SILVER, K;SHULDINER, AR
通讯作者：
SHULDINER, AR
影响因子：
158.5
作者：
STUNKARD, AJ;HARRIS, JR;MCCLEARN, GE
通讯作者：
MCCLEARN, GE