An Anatomic Substrate for Visual Disconnection in Alzheimer's Disease a
An Anatomic Substrate for Visual Disconnection in Alzheimer's Disease a
复制标题
阿尔茨海默氏病视觉脱节的解剖学基础
DOI：
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发表时间：
1991
影响因子：
5.2
通讯作者：
C. Bouras
中科院分区：
文献类型：
--
作者：
J. Morrison;P. Hof;C. Bouras
During a recent clinical and neuropathologic evaluation of a large population of brains collected at autopsy, attention was drawn to a subset of Alzheimer's disease (AD) patients presenting with prominent visual symptomatology as the first sign of the disease. In this population, a shift in the distribution of pathologic profiles had occurred such that the primary visual areas and the visual association areas had an increased number of lesions, whereas the prefrontal cortex had fewer lesions than usually observed in AD. Previous quantitative analyses have shown that generally in AD, primary sensory cortical areas are less damaged than association areas of the frontal and temporal lobes, as demonstrated by the laminar and regional distribution of two neuropathologic hallmarks of the disease, neurofibrillary tangles and neuritic plaques. Furthermore, the distribution of pathologic lesions in the AD cases with visual symptomatology revealed the disruption of specific visual association pathways, which are normally affected to a lesser degree in AD. These data suggest that in some cases of AD, the particular psychologic and neurologic symptomatology may be caused by the selective loss of specific corticocortical systems, as reflected by a differential distribution of the neuropathologic markers of the disease.
影响因子：
56.9
作者：
TSO, DY;FROSTIG, RD;GRINVALD, A
通讯作者：
GRINVALD, A