Discriminative stimulus properties of toluene in the mouse.
Discriminative stimulus properties of toluene in the mouse.
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甲苯对小鼠的辨别刺激特性。
DOI：
10.1016/0041-008x(87)90273-0
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发表时间：
1987
影响因子：
3.8
通讯作者：
Balster,RL
中科院分区：
文献类型：
--
作者：
Rees,DC;Knisely,JS;Jordan,S;Balster,RL
对于接触高浓度甲苯所产生的急性中毒的性质，如溢出和溶剂滥用者所产生的急性中毒，人们知之甚少。中毒可能类似于经典的中枢神经系统抑制剂，如巴比妥类药物。为了研究这一假设，使用药物辨别程序来比较甲苯和戊巴比妥（PB）产生的急性效应。训练小鼠在两级任务中区分甲苯（100 mg/kg，ip）和溶剂，其中响应受食物呈现的固定比率20（FR 20）时间表控制。在吸入暴露于甲苯（150 - 3600 ppm）20分钟后和注射PB（5 - 30 mg/kg）或吗啡（3 - 20 mg/kg）20分钟后进行泛化测试。大多数小鼠一般吸入甲苯和PB的浓度或剂量相关的方式，但不是吗啡。这些结果表明，注射甲苯的效果可以被确定为小鼠的辨别刺激，并且这些刺激效果与给药途径无关。与PB共享的辨别性刺激特性表明，甲苯像其他经典的CNS抑制剂一样产生急性中毒。
Little is known about the nature of the acute intoxication produced by exposure to high concentrations of toluene such as that which occurs with spills and in solvent abusers. The intoxication may be similar to that produced by classic central nervous system depressants such as the barbiturates. To investigate this hypothesis, drug discrimination procedures were used to compare the acute effects produced by toluene and pentobarbital (PB). Mice were trained to discriminate toluene (100 mg/kg, ip) from vehicle in a two-lever task in which responding was under the control of a fixed-ratio 20 (FR20) schedule of food presentation. Generalization tests were conducted after 20-min inhalation exposures to toluene (150–3600 ppm) and 20 min after injections with either PB (5–30 mg/kg) or morphine (3–20 mg/kg). Most mice generalized to inhaled toluene and to PB in a concentration- or dose-related fashion, but not to morphine. These results show that the effects of injected toluene can be established as a discriminative stimulus in mice, and that these stimulus effects are independent of route of administration. Shared discriminative stimulus properties with PB suggest that toluene produces an acute intoxication like that of other classic CNS depressants.
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甲苯的行为影响通过刺激控制来调节。
影响因子：
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作者：
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作者：
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DOI：
10.2131/jts.3.25
发表时间：
1978
期刊：
The Journal of toxicological sciences
影响因子：
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作者：
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DOI：
10.1007/978-1-4684-3189-6_7
发表时间：
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期刊：
The Journal of toxicological sciences
影响因子：
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作者：
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通讯作者：
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