Surface characterization and platelet adhesion studies of plasma-carboxylated polyethylene
Surface characterization and platelet adhesion studies of plasma-carboxylated polyethylene
复制标题
等离子体羧化聚乙烯的表面表征和血小板粘附研究
DOI：
10.1006/jcis.1993.1101
复制
发表时间：
1993
影响因子：
1.9
通讯作者：
S. Cooper
中科院分区：
文献类型：
--
作者：
T. Ko;Jui;S. Cooper
研究了犬血小板在二氧化硫(SO2)和烯丙基苯基砜[C6H5S(O)2CH2CH=CH2]等离子体处理的低密度聚乙烯(LDPE)上的粘附性。XPS和接触角实验证实，在13.56 MHz的射频激励下，这两种类型的辉光放电将亲水、含硫和含氧的官能团引入到LDPE基片上。对于这两种材料，含硫官能团的最高浓度都被5W的等离子体激发能结合在一起。总体而言，XPS研究表明二氧化硫等离子体比烯丙基苯砜等离子体具有更高的硫和亲水官能团的掺入水平。经等离子体处理后，表面亲水性大大提高。然而，由于亲水官能团扩散到材料的本体中，表面亲水性随着时间的推移而降低。这是由于疏水空气/LDPE界面的热力学驱动力使其保持较低的表面能级。烯丙基苯基砜等离子体处理的LDPE在血小板粘附性和铺展性方面比对照样品具有更好的抗凝血性。在不同等离子体激发能下反应的烯丙基苯基砜等离子体处理的LDPE样品，其血栓形成能力没有差异。二氧化硫等离子体处理的LDPE样品比未处理的LDPE样品对血小板的凝血作用更强。在二氧化硫等离子体处理的LDPE样品中，用5W的激发能制备的样品比用更高的等离子体激发能制备的样品具有更好的抗凝血性能。此外，在为本研究创建的所有等离子体磺化材料中，经5W二氧化硫等离子体处理的LDPE具有最高的硫原子浓度。
Canine platelet adhesion on sulfur dioxide (SO2) and allyl phenyl sulfone [C6H5S(O)2CH2CH=CH2] plasma treated low density polyethylene (LDPE) was studied. XPS and contact angle experiments confirmed the incorporation of hydrophilic sulfurcontaining and oxygen-containing functionalities onto flat sheets of LDPE substrates by these two types of glow discharges excited at a rf of 13.56 MHz. The highest concentration of sulfur-containing functional groups was incorporated by a 5 W plasma excitation energy for both types of materials. In general, XPS studies indicated higher levels of sulfur and hydrophilic functional group incorporation by the sulfur dioxide plasma than by the allyl phenyl sulfone plasma. Surface hydrophilicity increased drastically after the plasma treatment. However, the surface hydrophilicity decreased with time due to the diffusion of the hydrophilic functional groups into the bulk of the material. This was due to the thermodynamic driving force of the hydrophobic air/LDPE interface to maintain a low surface energy level. The allyl phenyl sulfone plasma treated LDPE was more thromboresistant than the control samples in terms of platelet adhesion and spreading. There was no difference in thrombogenicity for the allyl phenyl sulfone plasma treated LDPE samples which were reacted at different plasma excitation energies. Sulfur dioxide plasma treated LDPE samples were more thrombogenic toward platelets than the untreated LDPE samples. Among the sulfur dioxide plasma treated LDPE samples, the sample prepared using the 5 W excitation energy was more thromboresistant than the samples treated by higher plasma excitation energies. In addition, the 5 W sulfur dioxide plasma treated LDPE had the highest sulfur atomic concentration of all the plasma-sulfonated materials created for this study.
通过等离子体聚合改性的表面的血液相容性。
DOI：
10.1002/jbm.820220904
发表时间：
1988
期刊：
Journal of biomedical materials research
影响因子：
--
作者：
Yeh,YS;Iriyama,Y;Matsuzawa,Y;Hanson,SR;Yasuda,H
通讯作者：
Yasuda,H
人血小板对凝血因子 XII 和 XI 的蛋白水解激活的贡献。
影响因子：
20.3
作者：
Walsh,PN;Griffin,JH
通讯作者：
Griffin,JH