Accumulation of genetic changes is associated with poor prognosis in grade II astrocytomas.
Accumulation of genetic changes is associated with poor prognosis in grade II astrocytomas.
复制标题
遗传变化的积累与 II 级星形细胞瘤的不良预后相关。
作者：
S. Sallinen;P. Sallinen;H. Haapasalo;J. Kononen;R. Karhu;P. Helén;J. Isola
一些II级星形细胞瘤出乎意料的侵袭性临床过程是常规组织病理学诊断的难题。由于肿瘤恶性程度的增加是染色体变异进行性积累的结果，我们研究了II级星形细胞瘤的侵袭性行为是否可以通过大体染色体畸变的数量和类型来预测。我们使用比较基因组杂交分析了11例具有典型（良好，n = 7）或不良（n = 4）预后的II级星形细胞瘤。还将结果与13个III-IV级星形细胞瘤和9个已建立的细胞系的参考材料进行了比较。我们发现，在预后良好的肿瘤中，中位数为2个畸变（范围0至4），在预后不良的肿瘤中，中位数为15.5个变化（范围8至28）。两组均出现染色体获得，而染色体丢失在预后不良的肿瘤中常见（中位数9.5，范围3 - 14），但在预后良好的肿瘤中罕见（范围0 - 2）。所有的染色体增益也被发现在高级别星形细胞瘤组，其中大多数在细胞系。预后不良的II级星形细胞瘤中的染色体丢失与III-IV级星形细胞瘤和细胞系中的染色体丢失非常相似。我们的结论是，早期积累的II级星形细胞瘤的遗传变化是密切相关的患者预后不良，建议诊断使用比较基因组杂交的特征II级星形细胞瘤。
Unexpectedly aggressive clinical course of some grade II astrocytomas is a diagnostic dilemma for routine histopathology. Because increasing tumor malignancy is a consequence of progressive accumulation of chromosomal alterations, we investigated whether aggressive behavior of grade II astrocytomas could be predicted by the number and type of gross chromosomal aberrations. We used comparative genomic hybridization to analyze 11 grade II astrocytomas with typical (good, n = 7) or poor (n = 4) prognosis. The results were also compared with a reference material of 13 grade III-IV astrocytomas and nine established cell lines. We found a median of two aberrations (range 0 to 4) in tumors with good prognosis and of 15.5 changes (range 8 to 28) in tumors with poor prognosis. Chromosomal gains were present in both groups, whereas chromosomal losses were frequent in tumors with poor prognosis (median 9.5, range 3 to 14) but rare in tumors with good prognosis (range 0 to 2). All chromosomal gains were also found in the high-grade astrocytoma group and the majority of them in cell lines. Chromosomal losses in grade II astrocytomas with poor prognosis were very similar to those in grade III-IV astrocytomas and cell lines. We conclude that an early accumulation of genetic changes in grade II astrocytomas is closely associated with poor patient prognosis, suggesting diagnostic use for comparative genomic hybridization in characterization of grade II astrocytomas.
DOI：
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发表时间：
1995-10
期刊：
The American journal of pathology
影响因子：
--
作者：
J. Isola;O. Kallioniemi;L. Chu;S. Fuqua;S. Hilsenbeck;C. Osborne;F. Waldman
通讯作者：
J. Isola;O. Kallioniemi;L. Chu;S. Fuqua;S. Hilsenbeck;C. Osborne;F. Waldman
影响因子：
8.8
作者：
Hyytinen ER;Thalmann GN;Zhau HE;Karhu R;Kallioniemi OP;Chung LW;Visakorpi T
通讯作者：
Visakorpi T
影响因子：
56.9
作者：
KALLIONIEMI, A;KALLIONIEMI, OP;PINKEL, D
通讯作者：
PINKEL, D