Integration of evidence across human and model organism studies: A meeting report.
Integration of evidence across human and model organism studies: A meeting report.
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DOI：
10.1111/gbb.12738
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发表时间：
2021-04-23
期刊：
影响因子：
--
通讯作者：
Williams RW
中科院分区：
文献类型：
--
作者：
Palmer RHC;Johnson EC;Won H;Polimanti R;Kapoor M;Chitre A;Bogue MA;Benca-Bachman CE;Parker CC;Verma A;Reynolds T;Ernst J;Bray M;Kwon SB;Lai D;Quach BC;Gaddis NC;Saba L;Chen H;Hawrylycz M;Zhang S;Zhou Y;Mahaffey S;Fischer C;Sanchez-Roige S;Bandrowski A;Lu Q;Shen L;Philip V;Gelernter J;Bierut LJ;Hancock DB;Edenberg HJ;Johnson EO;Nestler EJ;Barr PB;Prins P;Smith DJ;Akbarian S;Thorgeirsson T;Walton D;Baker E;Jacobson D;Palmer AA;Miles M;Chesler EJ;Emerson J;Agrawal A;Martone M;Williams RW
橡树岭国家实验室的国家药物滥用研究所和生物科学联合研究所举办了一次会议，与会的科学家来自不同的领域，他们在药物使用障碍（SUD）、计算生物学和FAIR（可查找性、可访问性、互操作性和可重用性）数据共享方面具有专业知识。会议的目的是讨论和评估更好的策略，以整合人类和模型生物的遗传，表观遗传和组学数据，以实现对SUD的更深入的机制洞察。具体议题包括：（a）评估物质使用遗传学和基因组学研究的现状和根本差距，（B）确定跨物种和数据类型整合和共享的机遇和挑战，（c）确定整合遗传、表观遗传和表型数据的现有工具和资源，（d）讨论与数据整合有关的步骤和障碍，以及（e）概述支持更有效合作的未来步骤，特别是动物模型研究团体与人类遗传学和临床研究团队之间的合作。本次审查总结了这一催化性讨论的关键方面，重点是新的机会和资源和知识的差距。本报告讨论了知识的差距和成瘾功能发现下一阶段的可能性。
The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration—particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs. This report discusses gaps in knowledge and possibilities for the next phase of functional discovery for addiction.
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影响因子：
14.9
作者：
Baker EJ;Jay JJ;Bubier JA;Langston MA;Chesler EJ
通讯作者：
Chesler EJ
影响因子：
2.5
作者：
Churchill, Gary A.;Gatti, Daniel M.;Munger, Steven C.;Svenson, Karen L.
通讯作者：
Svenson, Karen L.
通过适应本地来进行全球：对最近的人类适应的评论。
DOI：
10.1126/science.aaf5098
发表时间：
2016-10-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fan S;Hansen ME;Lo Y;Tishkoff SA
通讯作者：
Tishkoff SA
影响因子：
11
作者：
Buchwald, Jadwiga;Chenoweth, Meghan J.;Tyndale, Rachel F.
通讯作者：
Tyndale, Rachel F.
影响因子：
11
作者：
Byrne EM;Zhu Z;Qi T;Skene NG;Bryois J;Pardinas AF;Stahl E;Smoller JW;Rietschel M;Bipolar Working Group of the Psychiatric Genomics Consortium;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium;Owen MJ;Walters JTR;O'Donovan MC;McGrath JG;Hjerling-Leffler J;Sullivan PF;Goddard ME;Visscher PM;Yang J;Wray NR
通讯作者：
Wray NR