Compromised SARS-CoV-2-specific placental antibody transfer.
Compromised SARS-CoV-2-specific placental antibody transfer.
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SARS-CoV-2特异性胎盘抗体转移受损。
DOI：
10.1016/j.cell.2020.12.027
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发表时间：
2021-02-04
期刊：
影响因子：
64.5
通讯作者：
Alter G
中科院分区：
文献类型：
--
作者：
Atyeo C;Pullen KM;Bordt EA;Fischinger S;Burke J;Michell A;Slein MD;Loos C;Shook LL;Boatin AA;Yockey LJ;Pepin D;Meinsohn MC;Nguyen NMP;Chauvin M;Roberts D;Goldfarb IT;Matute JD;James KE;Yonker LM;Bebell LM;Kaimal AJ;Gray KJ;Lauffenburger D;Edlow AG;Alter G
与年龄匹配的非孕妇相比，SARS-CoV-2感染会给孕妇带来更严重的疾病。目前尚不清楚母体感染是否会改变向婴儿的免疫转移。母体感染以前与胎盘抗体转移受损有关，但这种受损转移的机制尚未建立。在这里，我们使用系统血清学来表征跨胎盘转移的流感、百日咳和SARS-CoV-2特异性抗体的Fc谱。流感和百日咳特异性抗体被积极转移。然而，与流感和百日咳特异性抗体相比，SARS-CoV-2特异性抗体转移显著减少，脐带血滴度和功能活性低于母体血浆。这种影响只在妊娠晚期感染中观察到。SARS-CoV-2特异性转移与SARS-CoV-2抗体糖基化特征改变有关，感染诱导的IgG增加和FCGR3A胎盘表达增加部分挽救了SARS-CoV-2特异性转移。这些结果指出了意想不到的补偿机制来提高新生儿的免疫力，为产妇疫苗的设计提供了见解。SARS-CoV-2特异性抗体减少胎盘转移SARS-CoV-2尖峰抗体改变了妊娠晚期感染SARS-CoV-2的孕妇的糖基化状态，升高了免疫球蛋白水平SARS-CoV-2特异性抗体转移在中期感染Atyeo等人后有效。在妊娠晚期感染的妇女中，发现SARS-CoV-2抗体胎盘转移不足。虽然整体抗体转移保持不变，但SARS-CoV-2抗体表现出扰动的Fc糖基化特征和胎盘表达升高的免疫球蛋白和FCGR3A，这表明对较差的转移具有补偿作用。
SARS-CoV-2 infection causes more severe disease in pregnant women compared to age-matched non-pregnant women. Whether maternal infection causes changes in the transfer of immunity to infants remains unclear. Maternal infections have previously been associated with compromised placental antibody transfer, but the mechanism underlying this compromised transfer is not established. Here, we used systems serology to characterize the Fc profile of influenza-, pertussis-, and SARS-CoV-2-specific antibodies transferred across the placenta. Influenza- and pertussis-specific antibodies were actively transferred. However, SARS-CoV-2-specific antibody transfer was significantly reduced compared to influenza- and pertussis-specific antibodies, and cord titers and functional activity were lower than in maternal plasma. This effect was only observed in third-trimester infection. SARS-CoV-2-specific transfer was linked to altered SARS-CoV-2-antibody glycosylation profiles and was partially rescued by infection-induced increases in IgG and increased FCGR3A placental expression. These results point to unexpected compensatory mechanisms to boost immunity in neonates, providing insights for maternal vaccine design. SARS-CoV-2-specific antibodies have a decreased placental transfer SARS-CoV-2-spike antibodies have altered glycosylation profiles in pregnant women Pregnant women with SARS-CoV-2 during the third trimester have elevated IgG levels SARS-CoV-2-specific antibody transfer is efficient after second-trimester infection Atyeo et al. reveal a deficiency in SARS-CoV-2-antibody placental transfer among women infected during the third trimester. While bulk antibody transfer remains unaltered, SARS-CoV-2-antibodies show perturbed Fc glycosylation profiles and elevated IgG and FCGR3A placental expression that suggest compensation for poor transfer.
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影响因子：
6.4
作者：
Atwell, Jessica E.;Thumar, Bhagvanji;Karron, Ruth A.
通讯作者：
Karron, Ruth A.
DOI：
10.1073/pnas.2004325117
发表时间：
2020-06-09
影响因子：
11.1
作者：
Borghi, Sara;Bournazos, Stylianos;Wang, Taia T.
通讯作者：
Wang, Taia T.
影响因子：
3.8
作者：
Castanha, Priscila M. S.;Souza, Wayner V.;Brandao Filho, Sinval Pinto
通讯作者：
Brandao Filho, Sinval Pinto
影响因子：
13.8
作者：
Edlow AG;Li JZ;Collier AY;Atyeo C;James KE;Boatin AA;Gray KJ;Bordt EA;Shook LL;Yonker LM;Fasano A;Diouf K;Croul N;Devane S;Yockey LJ;Lima R;Shui J;Matute JD;Lerou PH;Akinwunmi BO;Schmidt A;Feldman J;Hauser BM;Caradonna TM;De la Flor D;D'Avino P;Regan J;Corry H;Coxen K;Fajnzylber J;Pepin D;Seaman MS;Barouch DH;Walker BD;Yu XG;Kaimal AJ;Roberts DJ;Alter G
通讯作者：
Alter G
DOI：
10.1016/j.ajogmf.2020.100118
发表时间：
2020-05-01
影响因子：
6.3
作者：
Breslin, Noelle;Baptiste, Caitlin;Goffman, Dena
通讯作者：
Goffman, Dena