Blood Groups Distribution and Gene Diversity of the ABO and Rh (D) Loci in the Mexican Population.
Blood Groups Distribution and Gene Diversity of the ABO and Rh (D) Loci in the Mexican Population.
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DOI：
10.1155/2018/1925619
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发表时间：
2018
影响因子：
--
通讯作者：
Alcántar-Fernández J
中科院分区：
文献类型：
--
作者：
Canizalez-Román A;Campos-Romero A;Castro-Sánchez JA;López-Martínez MA;Andrade-Muñoz FJ;Cruz-Zamudio CK;Ortíz-Espinoza TG;León-Sicairos N;Gaudrón Llanos AM;Velázquez-Román J;Flores-Villaseñor H;Muro-Amador S;Martínez-García JJ;Alcántar-Fernández J
确定ABO和Rh（D）抗原的频率和分布，并调查墨西哥人群的基因多样性和结构。 从2014年到2016年，对271，164名受试者进行了血型检测。分别使用Rh因子的抗A、抗B和抗D抗体通过凝集法确定ABO血型。 ABO和Rh（D）血型在研究人群中的总体分布如下：O型：61.82%; A型：27.44%; B型：8.93%; AB型：1.81%。在Rh血型中，95.58%的人是Rh（D）型，4.42%的人是Rh（d）型。不同地区的血型分布存在差异，遗传分析显示IO和ID等位基因从北部向中部逐渐增加，IA和Id等位基因从中部向北部逐渐增加。此外，我们发现更多的基因多样性在这两个位点在北部相比，中心，这表明在墨西哥的人口结构。 这项工作可以帮助卫生机构确定在哪里可以获得医疗干预所需的血液制品。此外，这一信息有助于了解墨西哥人口的遗传结构，这可能对生物医学的不同领域产生重大影响。
To determine the frequency and distribution of ABO and Rh (D) antigens and, additionally, investigate gene diversity and the structure of Mexican populations. Blood groups were tested in 271,164 subjects from 2014 to 2016. The ABO blood group was determined by agglutination using the antibodies anti-A, Anti-B, and Anti-D for the Rh factor, respectively. The overall distribution of ABO and Rh (D) groups in the population studied was as follows: O: 61.82%; A: 27.44%; B: 8.93%; and AB: 1.81%. For the Rh group, 95.58% of people were Rh (D), and 4.42% were Rh (d). Different distributions of blood groups across regions were found; additionally, genetic analysis revealed that the IO and ID allele showed an increasing trend from the north to the center, while the IA and Id allele tended to increase from the center to the north. Also, we found more gene diversity in both loci in the north compared with the center, suggesting population structure in Mexico. This work could help health institutions to identify where they can obtain blood products necessary for medical interventions. Moreover, this piece of information contributes to the knowledge of the genetic structure of the Mexican populations which could have significant implications in different fields of biomedicine.
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影响因子：
3.5
作者：
Fry AE;Griffiths MJ;Auburn S;Diakite M;Forton JT;Green A;Richardson A;Wilson J;Jallow M;Sisay-Joof F;Pinder M;Peshu N;Williams TN;Marsh K;Molyneux ME;Taylor TE;Rockett KA;Kwiatkowski DP
通讯作者：
Kwiatkowski DP
影响因子：
2.6
作者：
Arnaiz-Villena, A.;Moscoso, J.;Vargas-Alarcon, G.
通讯作者：
Vargas-Alarcon, G.
影响因子：
15.3
作者：
Landsteiner, K;Wiener, AS;Matson, GA
通讯作者：
Matson, GA
DOI：
10.1126/science.1251688
发表时间：
2014-06-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Moreno-Estrada A;Gignoux CR;Fernández-López JC;Zakharia F;Sikora M;Contreras AV;Acuña-Alonzo V;Sandoval K;Eng C;Romero-Hidalgo S;Ortiz-Tello P;Robles V;Kenny EE;Nuño-Arana I;Barquera-Lozano R;Macín-Pérez G;Granados-Arriola J;Huntsman S;Galanter JM;Via M;Ford JG;Chapela R;Rodriguez-Cintron W;Rodríguez-Santana JR;Romieu I;Sienra-Monge JJ;del Rio Navarro B;London SJ;Ruiz-Linares A;Garcia-Herrera R;Estrada K;Hidalgo-Miranda A;Jimenez-Sanchez G;Carnevale A;Soberón X;Canizales-Quinteros S;Rangel-Villalobos H;Silva-Zolezzi I;Burchard EG;Bustamante CD
通讯作者：
Bustamante CD
影响因子：
3.7
作者：
Flegr, Jaroslav
通讯作者：
Flegr, Jaroslav