Association of BCL2 polymorphisms and the IL19 single nucleotide polymorphism rs2243188 with systemic lupus erythematosus.
Association of BCL2 polymorphisms and the IL19 single nucleotide polymorphism rs2243188 with systemic lupus erythematosus.
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DOI：
10.1177/03000605211019187
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Fan Y
中科院分区：
文献类型：
--
作者：
Wang W;Wang X;Yang K;Fan Y
B细胞淋巴瘤2（Bcl-2）和白细胞介素19（IL-19）的异常表达与系统性红斑狼疮（SLE）的发病密切相关。我们的目的是确定BCL 2多态性和IL 19的单核苷酸多态性（SNP）是否与SLE易感性显著相关，以及这是否受到IL 19和BCL 2基因型之间协同作用的影响。这项观察性队列研究随机招募了150名SLE患者和150名健康对照者。检测两组患者BCL 2和IL 19的主要等位基因和基因型分布。使用TaqMan-MGB探针方法确定IL 19 SNP rs 2243188。分析BCL 2和IL 19的协同作用与SLE临床症状的关系。BCL 2主要基因型和常见等位基因的分布，特别是基因型191，193和197，在患者和对照组之间存在显著差异。显性遗传模型的显着差异也观察到组间，但不是在隐性模型。携带195 bp BCL 2和138 bp IL 19易感等位基因的个体的疾病风险高于仅携带任一等位基因的个体。提示BCL 2基因多态性和IL 19基因多态性rs 2243188与SLE发病密切相关。
Abnormal B cell lymphoma-2 (Bcl-2) and interleukin-19 (IL-19) expression is closely related to systemic lupus erythematosus (SLE) pathogenesis. We aimed to determine whether BCL2 polymorphisms and a single nucleotide polymorphism (SNP) of IL19 are significantly associated with SLE susceptibility and if this is affected by synergism between IL19 and BCL2 genotypes. This observational cohort study randomly enrolled 150 patients with SLE and 150 healthy controls. Major BCL2 and IL19 allele and genotype distributions were examined in the two groups. The IL19 SNP rs2243188 was determined using the TaqMan-MGB probe method. The synergistic effect between BCL2 and IL19 and clinical symptoms of SLE was also analyzed. The distribution of major BCL2 genotypes and common BCL2 alleles, especially for genotypes 191, 193, and 197, differed significantly between patients and controls. A significant difference in the dominant genetic model was also observed between groups, but not in the recessive model. The risk of disease in individuals who carried both 195-bp BCL2 and 138-bp IL19 susceptibility alleles was higher than in those carrying either allele alone. This preliminary study suggested that BCL2 polymorphisms and the IL19 SNP rs2243188 are closely related to the pathogenesis of SLE.
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