Comparative effectiveness on survival of zoledronic acid versus pamidronate in multiple myeloma.
Comparative effectiveness on survival of zoledronic acid versus pamidronate in multiple myeloma.
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DOI：
10.3109/10428194.2014.924117
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发表时间：
2015-03
影响因子：
2.6
通讯作者：
Carson K
中科院分区：
文献类型：
--
作者：
Sanfilippo KM;Gage B;Luo S;Weilbaecher K;Tomasson M;Vij R;Colditz G;Carson K
唑来膦酸和帕米膦酸盐是两种在美国获批用于减少多发性骨髓瘤骨骼并发症的双膦酸盐。很少有证据比较两者之间的生存结果。我们评估了骨髓瘤患者接受唑来膦酸和帕米膦酸盐治疗的骨骼相关事件的发生率和总生存率，研究对象为1,018名美国退伍军人。在中位随访26.9个月时，与帕米膦酸盐相比，接受唑来膦酸治疗的患者死亡风险降低22%（风险比（HR）0.78; 95%CI，0.67-0.92）。在控制潜在混杂因素后，获益持续存在。调整后的考克斯模型与逆概率加权和倾向评分匹配支持这些结果。唑来膦酸也与尿道相关事件减少25%相关。与帕米膦酸盐相比，唑来膦酸与多发性骨髓瘤患者的总生存率增加和骨骼相关事件减少相关，应成为首选的双膦酸盐。
Zoledronic acid and pamidronate are the two bisphosphonates approved to reduce multiple myeloma skeletal complications in the United States. Little prior evidence exists comparing survival outcomes between the two. We evaluated the incidence of skeletal related events and overall survival in myeloma patients treated with zoledronic acid versus pamidronate using a cohort of 1,018 United States Veterans. At median follow-up of 26.9 months, patients receiving zoledronic acid had a 22% reduction in risk of death compared to pamidronate (hazard ratio (HR) 0.78; 95% CI, 0.67–0.92). The benefit persisted after controlling for potential confounders. Adjusted Cox modeling with inverse probability weighting and propensity score matching supported these findings. Zoledronic acid was also associated with a 25% decrease in skeletal-related events. Zoledronic acid is associated with increased overall survival and decreased skeletal related events compared to pamidronate in patients with multiple myeloma and should become the preferred bisphosphonate.
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影响因子：
3.3
作者：
Sohn MW;Arnold N;Maynard C;Hynes DM
通讯作者：
Hynes DM
影响因子：
--
作者：
Oranger A;Carbone C;Izzo M;Grano M
通讯作者：
Grano M
DOI：
10.1196/annals.1402.089
发表时间：
2007-01-01
期刊：
SKELETAL BIOLOGY AND MEDICINE, PT B
影响因子：
--
作者：
Russell, R. Graham G.;Xia, Zhidao;Ebetino, Frank H.
通讯作者：
Ebetino, Frank H.
影响因子：
4.3
作者：
McCarthy, Philip L., Jr.;Hahn, Theresa;Hassebroek, Anna;Bredeson, Christopher;Gajewski, James;Hale, Gregory;Isola, Luis;Lazarus, Hillard M.;Lee, Stephanie J.;LeMaistre, Charles F.;Loberiza, Fausto;Maziarz, Richard T.;Rizzo, J. Douglas;Joffe, Steven;Parsons, Susan;Majhail, Navneet S.
通讯作者：
Majhail, Navneet S.
影响因子：
6.4
作者：
Guenther, Andreas;Gordon, Sharon;Gramatzki, Martin
通讯作者：
Gramatzki, Martin