Prognostic value of total tumor volume in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.
Prognostic value of total tumor volume in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.
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肿瘤总体积对鼻咽癌调强放疗患者的预后价值
DOI：
10.1186/s12885-017-3480-5
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发表时间：
2017-07-28
期刊：
影响因子：
3.8
通讯作者：
Fu LW
中科院分区：
文献类型：
--
作者：
Liang SB;Teng JJ;Hu XF;Yang XL;Luo M;Fang XN;Liu DS;Chen Y;Fu LW
BackgroundFew studies have evaluated the prognostic value of total tumor volume (TTV), which reflects both the primary tumor volume and nodal tumor volume, in NPC. Furthermore, the relationship between TTV and survival remains unknown. The purpose of this study was to evaluate the prognostic value of TTV in patients with NPC treated with intensity-modulated radiation therapy (IMRT).MethodsTTV was retrospectively assessed in 455 patients with newly diagnosed, non-metastatic NPC. All patients were treated using IMRT; 91.1% (288/316) of patients with stage III-IVb also received cisplatin-based chemotherapy. Receiver operating characteristic (ROC) curves were used to identify the optimal TTV cut-off point and examine the prognostic value of combined TTV with current clinical stage.ResultsMean TTV was 11.1 cm3(range, 0.3–27.9 cm3) in stage I, 22.5 cm3(1.3–92.4 cm3) in stage II, 40.6 cm3in stage III (3.2–129.2 cm3), and 77.5 cm3in stage IVa-b (7.1–284.1 cm3). For all patients, the 4-year estimated FFS, OS, DMFS, and LRRFS rates for patients with a TTV ≤ 28 vs. > 28 cm3were 93 vs. 71.4% (P< 0.001), 95.1 vs. 75.4% (P< 0.001), 94.5 vs. 79.4% (P< 0.001), and 96.2 vs. 88% (P= 0.001). TTV was an independent prognostic factor for FFS, OS, DMFS and LRRFS in all patients. In stage III-IVb, 4-year estimated FFS, OS, DMFS, and LRRFS for a TTV ≤28 vs. >28 cm3were 88.9 vs. 70.5% (P= 0.001), 96.2 vs. 72.7% (P< 0.001), 91.2 vs. 78.3% (P= 0.008), and 93.8 vs. 87.6% (P= 0.063). TTV was an independent prognostic factor for FFS, OS and DMFS in stage III-IVb. Receiver operating characteristic (ROC) curve analysis curves revealed adding TTV to clinical stage had superior prognostic value for treatment failure compared to clinical stage alone (P= 0.016).ConclusionsTTV is an important prognosticator for treatment outcome and significantly improves the prognostic value of the current staging system for patients with NPC treated with IMRT.
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原发肿瘤体积是否仍是鼻咽癌调强放射治疗的预后因素？
影响因子：
5.7
作者：
Guo, Rui;Sun, Ying;Ma, Jun
通讯作者：
Ma, Jun
影响因子：
4.8
作者：
Ng, Wai Tong;Lee, Michael C. H.;Lee, Anne W. M.
通讯作者：
Lee, Anne W. M.
影响因子：
4.8
作者：
Zhang, Han;Seikaly, Hadi;O'Connell, Daniel A.
通讯作者：
O'Connell, Daniel A.
影响因子：
3.8
作者：
Liang SB;Deng YM;Zhang N;Lu RL;Zhao H;Chen HY;Li SE;Liu DS;Chen Y
通讯作者：
Chen Y
DOI：
10.1186/1748-717x-8-87
发表时间：
2013-04-11
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Wu Z;Gu MF;Zeng RF;Su Y;Huang SM
通讯作者：
Huang SM