Mechanisms of chronic infection, immunotolerance and coevolution in avian circovirus infections

该项目将产生新的基础知识，在广泛的动物宿主的持续性，慢性病毒性疾病的发病机制。此外，根据《濒危物种保护法》（1992年），喙羽病病毒被列为至少16种澳大利亚濒危鸟类的关键威胁过程。关于感染早期发生的宿主与病毒的相互作用，以及为什么一些鸟类康复，而另一些则发展为全面疾病，人们知之甚少。该项目将提供新的知识，可用于抵消其对当前和未来濒危物种恢复计划的影响。

This project will generate fundamental new knowledge into the pathogenesis of persistent, chronic viral diseases in a wide range of animal hosts. Furthermore, beak and feather disease virus is listed as a Key Threatening Process under the Endangered Species Protection Act (1992) to at least sixteen endangered Australian bird species. Very little is known about the host-virus interactions that occur during the early stages of infection or why some birds recover yet others develop full blown disease. This project will provide new knowledge that can be used to counteract its effects on current and future endangered species recovery program.