Optimising the efficacy of mycoplasma vaccines in the field

优化支原体疫苗在野外的疗效。本项目旨在研究抗生素处理、灭活疫苗和免疫抑制病毒对新型鸡脓毒支原体模型疫苗诱导保护性免疫的影响。致病性支原体在集约化管理的动物中持续传播是一个主要的动物健康问题。减毒活疫苗可以减少疾病，但我们对使用它们的最佳条件了解有限。该项目将产生数据，以指导支原体活疫苗的使用和开发。通过减少抗生素的使用来控制支原体，预计将对动物健康、福利和生产以及公共卫生产生重大影响。

Optimising the efficacy of mycoplasma vaccines in the field. This project intends to examine the effect of antibiotic treatment, killed vaccines and immunosuppressive viruses on the protective immunity induced by a model novel vaccine against the important poultry pathogen Mycoplasma gallisepticum. The continued circulation of pathogenic mycoplasmas in intensively managed animals is a major animal health problem. Live attenuated vaccines could reduce disease, but we have limited understanding of the best conditions for their use. This project will generate data to guide both use and development of live mycoplasma vaccines. It is expected to have significant impacts on animal health, welfare and production, and public health by reducing the use of antibiotics to control mycoplasmoses.