Approaches to regulate Cbl ubiquitin ligase activity and control oncogenic tyrosine kinase signaling.

白血病是儿童和青少年最常见的癌症，约占儿童癌症的三分之一。最近，一种蛋白Cbl在儿童白血病中被发现存在突变。这些突变阻碍了Cbl发挥其乐趣

Leukemia is the most common cancer in children and adolescents, accounting for about one out of three cancers in children. Recently, a protein Cbl has been found to have mutations in childhood leukemia. These mutations prevent Cbl from performing its fun