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Inhibition of retroviral replication by the restriction factor TRIM5alpha, and its applications

Inhibition of retroviral replication by the restriction factor TRIM5alpha, and its applications
限制因子TRIM5α抑制逆转录病毒复制及其应用
批准号:
189010
负责人:
Berthoux Lionel
金额:
$35.31万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2009
资助国家:
加拿大
项目状态:
已结题
起止时间:
2009-09-01 至 2014-09-01

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中文摘要
翻译
TRIM5Alpha是逆转录病毒的天然抑制剂,逆转录病毒是包括艾滋病毒-1和艾滋病病毒在内的病毒家族。不幸的是,HIV-1 不受人类版本的TRIM5pha的影响,但在其他灵长类动物中,它有效地被这种蛋白抑制。我的实验室
英文摘要
TRIM5alpha is a natural inhibitor of retroviruses, a family of viruses that includes HIV-1, the AIDS virus. Unfortunately, HIV-1 is not affected by the human version of TRIM5alpha, but it is efficiently inhibited by this protein in other primates. My labo
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The interplay between TRIM5alpha and autophagy in the activation of the innate immune response to HIV-1
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