Investigation into RAS GTPase control of cell adhesion and proliferation through alternative downstream effectors
Investigation into RAS GTPase control of cell adhesion and proliferation through alternative downstream effectors
批准号:
443419
负责人:
Smith Matthew J
金额:
$55.45万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2021
资助国家:
加拿大
项目状态:
未结题
起止时间:
2021-04-01 至 2026-04-01
中文摘要
人体内各种细胞类型的遗传物质的异常变化可能导致癌症,或者更具体地说,细胞的不受控制的增殖。当这种情况发生时,受影响的基因会产生蛋白质,这些蛋白质在正常情况下不能被关闭。
英文摘要
Abnormal changes to the genetic material of various cell types in the human body can lead to cancer, or more specifically the uncontrolled proliferation of cells. When this occurs, the affected genes create proteins that cannot be turned off in a normal f
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会议论文
Regulation of RAS driven cellular proliferation by SHOC2 and the MRAS GTPase
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批准号:478191
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项目类别:Operating Grants
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资助金额:$60.19万
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财政年份:2023
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负责人:Smith Matthew J
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依托单位:
Canada Research Chair - Tier 2
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批准号:459703
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项目类别:
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资助金额:$36.43万
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财政年份:2021
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负责人:Smith Matthew J
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依托单位:
Canada Research Chair Tier 2
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批准号:373614
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项目类别:
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资助金额:$36.43万
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财政年份:2016
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负责人:Smith Matthew J
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依托单位:
Real-time surveillance of multiplexed, reversible cancer signalling markers in perturbed RAS networks
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批准号:365595
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项目类别:Operating Grants
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资助金额:$7.07万
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财政年份:2016
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负责人:Smith Matthew J
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依托单位:
Elucidation of the molecular mechanisms governing currently untargeted RAS effector pathways towards novel therapeutic approaches for the most refractory human cancers
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批准号:343870
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项目类别:Operating Grants
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资助金额:$58.76万
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财政年份:2016
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负责人:Smith Matthew J
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依托单位: