Defining the molecular mechanisms that direct Heat Shock Proteins to neuronal projections in response to proteotoxic damage
Defining the molecular mechanisms that direct Heat Shock Proteins to neuronal projections in response to proteotoxic damage
批准号:
468536
负责人:
Vera Ugalde Maria
金额:
$56.29万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-09-01 至 2027-09-01
中文摘要
发达国家的寿命延长导致各种与年龄相关的神经退行性疾病的患病率更高。它们被称为“蛋白质构象疾病”,因为神经元功能障碍的共同原因是线粒体的毒物沉积。
英文摘要
Increased lifespan in developed countries has led to a higher prevalence of diverse age-related neurodegenerative disorders. They are known as "protein conformational diseases" because the common cause of the neuronal malfunction is the toxic deposit of m
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