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Cell biological basis of a newly identified form of developmental and epileptic encephalopathy caused by variants in DENND5A, a guanine nucleotide exchange factor for Rab GTPases

Cell biological basis of a newly identified form of developmental and epileptic encephalopathy caused by variants in DENND5A, a guanine nucleotide exchange factor for Rab GTPases
由 DENND5A 变异引起的一种新发现的发育性和癫痫性脑病的细胞生物学基础,DENND5A 是 Rab GTP 酶的鸟嘌呤核苷酸交换因子
批准号:
489016
负责人:
McPherson Peter S
金额:
$80.25万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-09-01 至 2028-09-01

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中文摘要
翻译
神经系统的发育是一个非常复杂的过程。在大脑发育过程中,称为神经祖细胞的干细胞形式有两个作用,首先,它们需要增殖以确保大脑具有适当数量的细胞,
英文摘要
The development of the nervous system is a highly complex process. During brain development, forms of stem cells called neural progenitors have two roles, first, they need to proliferate to ensure that the brain has the appropriate number of cells, and se
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