Metabolism of Circulating Hormones by the Fish Gill

鱼鳃是鱼和鱼的环境之间的主要界面。鳃在呼吸和调节离子和水分平衡中起着重要作用。因此，控制流经该器官的血液流动对于维持体内体液平衡至关重要。奥尔森博士计划对血液中调节鳃血管网络血流的激素和激素样因子的作用和代谢进行一系列研究。Olson博士开发了一种鳃灌注程序，允许在存在和不存在各种药物（如血管紧张素、缓激肽、生物胺和其他已知的其他组织中血液流动调节剂的化合物）的情况下测量血流量、血压等。他已经调整了这个程序，这样他就可以测量这些化合物通过鳃时鳃组织对它们的吸收和代谢。然后，他将能够将血管变化与代谢事件联系起来，并确定哪些因素是调节血液流动的主要因素。该研究结果对我们了解呼吸器官的血流调节具有重要意义。此外，这些结果将有助于我们了解鳃组织的激素代谢，以及环境因素（即污染物）的作用，这些因素可能会损害鳃，从而干扰通过鳃的血液流动，破坏应激鱼体内的激素平衡。

The fish gill is the primary interface between the fish and the fish's environment. The gill plays a major role in respiration and in the regulation of ion and water balance. Control of blood flow through this organ is then of primary importance in the maintenance of internal body fluid homeostasis. Dr. Olson plans a series of studies on the action and metabolism of hormones and hormone-like factors in the blood that regulate blood flow through the gill vascular network. Dr. Olson has developed a gill perfusion procedure that allows measurement of blood flow, blood pressure, etc. in the presence and absence of various agents such as angiotensin, bradykinin, biogenic amines, and other compounds that are known to be regulators of blood flow in other tissues. He has adapted the procedure so that he will be able to measure the uptake and metabolism of these compounds by the gill tissue as they pass through the gill. He will then be able to correlate vascular changes with the metabolic events and determine which of these factors are the major actors in the regulation of blood flow. The research results are of primary importance to our understanding of the regulation of blood flow in respiratory organs. In addition the results will contribute to our understanding of hormone metabolism by gill tissue and to the role of environmental factors (i.e. pollutants) that might damage the gills and thereby disturb blood flow through the gills and upset hormone balance within the stressed fish.