International Symposium on Bombesin-Like Peptides

在过去的几年里，关于神经肽等小分子是如何对身体和大脑产生影响的，人们已经了解了很多。本次会议的目的是对蛙素样肽研究的各个方面和此类发现的应用进行深入的综述。炸弹领域的进展因三个体面的事态发展而加快。首先，展示了蛙皮素影响肠道功能和动态平衡的中枢调节的强大生物活性。其次，哺乳动物蛙皮素样肽的特性，称为胃泌素释放肽(GRP)，以及随后人类GRP基因的克隆。第三，发现蛙皮素和哺乳动物相关肽在人小细胞肺癌中是一种重要的自分泌型生长因子。这些发现引起了人们的兴趣和多学科研究的激增。受邀的演讲者将讨论与以下主题有关的问题：1)蛙皮素样肽的化学和分子生物学，包括克隆和蛙皮素基因及其翻译产物的鉴定，2)蛙皮素样肽的组织分布和含量；3)蛙皮素受体，定位，竞争性抗激动剂的表征和开发进展，4)多肽的细胞、外周和中枢神经系统作用。会议将首次为神经学家、解剖学家、药理学家、胃肠病学家、分子生物学家和肿瘤学家提供一个论坛，以更新目前关于蛙皮素类多肽的研究活动，并勾勒出进一步发展的领域，并确定未来几年的方向，特别是这些多肽在正常和恶性组织生长和肠道功能调节中的作用。作为这次会议的成果，纽约科学院将出版的这本书将是关于这一主题的第一本综合性专著。

In the past few years, much has been learned about how small molecules like neuropeptides exert influence on the body and brain. The objectives of this conference are to provide an in- depth review of the various aspects of bombesin-like peptide research and applications of such findings. Progress in the bombesin field has been accelerated by three decent developments. First, was the demonstration of the potent biological activity of bombesin to influence gut function and the central regulation of homeostasis. Secondly, the characterization of mammalian bombesin-like peptides, called gastrin releasing peptide (GRP) and the subsequent cloning of the human GRP gene. Thirdly, was the discovery that bombesin and mammalian related peptides acts as an important autocrine type growth factor in human small cell lung cancer. These findings have lead to a proliferation of interest and multidisciplinary studies. Invited speakers will address issues related to the following topics: 1) Chemistry and molecular biology of bombesin-like peptides including cloning and characterization of bombesin cDNA and the translational products of bombesin genes, 2) Tissue distribution and content of bombesin-like peptides, 3) Bombesin receptors, localization, characterization and progress in the development of competitive anatagonists, 4) Cellular, peripheral and central nervous system actions of the peptide. The meeting will provide for the first time a forum for neuroscientists, anatomists, pharacologists, gastroenterologists, molecular biologists and oncologists to update current research activities on bombesin-like peptides and also to delineate the areas for further development and set up directions for coming years particularly the role of these peptides in normal and malignant tissue growth and regulation of gut function. The book to be published by the New York Academy of Sciences as a result of the meeting will be the first comprehensive monograph on the subject.