Androgen receptor: A master regulator of lipid metabolism

这个项目旨在了解男性荷尔蒙或雄激素如何影响正常身体组织中脂肪的数量和新陈代谢。通过将我们在雄激素作用、分子生物学、新陈代谢和生物信息学方面的多学科专业知识与新技术和仪器相结合，这项合作有望产生关于人类脂肪代谢如何受到雄激素控制以及这与小鼠有多密切关系的第一张详细图片。预期的结果和益处将是对脂肪代谢的哪些方面受雄激素影响最大的新理解，以及预测人类、实验动物和牲畜雄激素水平自然或药物波动的潜在代谢影响的能力。

This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this relates to mice. Expected outcomes and benefits will be a new understanding of which aspects of fat metabolism are most influenced by androgens, and an ability to anticipate potential metabolic impacts of natural or pharmacological fluctuations in androgen levels in humans, laboratory animals and livestock.