Purchase of Automatic X-Ray Diffractometer (Chemistry)

X射线结晶学技术是确定从小肽到复杂金属簇的各种化合物分子结构的有力工具。当与最新的计算机软件相结合时，这项技术变得非常容易实施。X射线晶体仪器的获得显著提高了化学家开展前沿研究的能力。在化学共享仪器计划和美国国立卫生研究院的资助下，德克萨斯大学奥斯汀分校化学系将购买一台自动衍射仪和适当的外围附件，以建立X射线衍射仪设施。收购该仪器将增强的化学领域包括：1)溶液中的阳离子自由基周环反应2)离子的光化学和电化学机理，激进分子，和自由基离子3)三氯乙烯仿生方法的发展4)具有生物重要性的有机金属结构5)共价结合药物-DNA加合物结构的测定6)基于配体的过渡金属性质的系统修饰7)铬配合物的合成与性质8)生物活性天然产物的结构与功能关系9)光解或热解反应中间体的研究10)新型大环化合物的合成11)天然产物的合成12)合成和生物有机化学

The technique of X-ray crystallography is a powerful tool for the determination of the molecular structure of compounds as diverse as small peptides and complex metal clusters. When combined with the latest computer software, the technique is becoming remarkably easy to put into practice. The acquisition of X-ray crystallographic instrumentation markedly improves the ability of chemists to carry out frontier research. With the aid of awards from the Chemistry Shared Instrumentation Program and NIH, the Department of Chemistry at the University of Texas at Austin will purchase an automatic diffractometer and the appropriate peripheral accessories to establish an X-ray diffractometry facility. The areas of chemistry that will be enhanced by the acquisition of the instrumentation include: 1) Cation Radical Pericyclic Reactions in Solution 2) Mechanisms of the Photochemistry and Electrochemistry of Ions, Radicals, and Radical Ions 3) Development of a Biomimetic Approach to Trichothecenes 4) Organometallic Structures of Biological Importance 5) Determination of the Structure of Covalently Bound Drug-DNA Adducts 6) Ligand-based Systematic Modification of Properties of Transition Metals 7) Synthesis and Properties of Chromium Complexes 8) Relationship between Structure and Function of Bioactive Natural Products 9) Study of Reactive Intermediates Generated by Photolysis or Thermolysis 10) The Synthesis of Novel Macrocyclic Compounds 11) Synthesis of Natural Products 12) Synthetic and Bioorganic Chemistry