Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function

该项目的目的是确定编码天然淋巴细胞及其识别的分子表达的细胞表面受体的基因的遗传变异如何使其感知和应对感染的能力多样化。这些知识对于理解为什么个体之间在应对不同类型感染的能力方面存在内在差异至关重要，并最终将使我们有能力更好地部署个性化药物。

The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultimately inform our capacity to better deploy personalised medicines.