Investigation of small molecule interactions with the human leukocyte antigen and their role in non-infectious disease

研究小分子与人类白细胞抗原的相互作用及其在非传染性疾病中的作用

• 批准号: nhmrc : 1072159
• 负责人: Dr Patricia Illing
• 金额: $ 21.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-small-molecule-infectious-disease/455497
• 关键词: Investigation; small; molecule; interactions; human

The Human Leukocyte Antigens (HLA) play a key role in the immune system helping the body differentiate healthy from diseased cells. Numerous autoimmune diseases and adverse drug reactions are associated with specific HLA variants. This study seeks to unlock the mechanisms behind these diseases, investigating how small molecules including drugs interact with the HLA to make healthy body cells seem foreign. This research has the potential to inform strategies for disease avoidance and management.

人类白细胞抗原（HLA）在免疫系统中发挥关键作用，帮助身体区分健康细胞和病变细胞。许多自身免疫性疾病和药物不良反应与特定的HLA变异有关。这项研究试图揭开这些疾病背后的机制，研究包括药物在内的小分子如何与HLA相互作用，使健康的身体细胞看起来是外来的。这项研究有可能为疾病的预防和管理策略提供信息。