UW Biotechnology Center: Hybridoma and Transgenic Mouse Facilities

该提案要求提供资金，以扩大现有的混合基金 设施，并建立一个新的转基因小鼠设施。 的 混合设施将包含设备和用品，以及 为生产单克隆抗体提供技术援助 生物学研究所需的抗体。 重大项目 包括：核糖体结构的研究，RNA聚合酶 sigma因子、肉毒杆菌毒素、雌激素受体和小 核核糖核蛋白颗粒。 转基因小鼠 设施将作为一种服务，并提供专业知识， 转基因小鼠的生产和遗传分析。 的 该设施的主要目标是生产小鼠模型， 用于研究人类遗传疾病和研究遗传 控制生理过程或转基因小鼠模型， 对基因的研究，这些基因在改变 或食用动物的产品成分。 支持是 推荐

This proposal requests funds to augment the existing Hybridoma Facility and to create a new Transgenic Mouse Facility. The Hybridoma Facility will contain equipment and supplies as well as provide the technical assistance for the production of monoclonal antibodies required for biological research. Major projects include: studies of the structure of ribosomes, RNA polymerase sigma factors, Botulism toxin, estrogen receptors, and small nuclear ribonucleoprotein particles. The Transgenic Mouse Facility will perform as a service and provide expertise in the production and genetic analysis of transgenic mice. The principal objectives of the facility are to produce mouse models for the study of human genetic disorders and to study the genetic control of physiological processes or transgenic mouse models for the study of genes that are important in altering the efficiency or product composition of food-producing animals. Support is recommended.