Synthesis and Chemistry of Bridgehead Alkenes

Kenneth J. Shea博士的这项研究计划将得到支持 化学系有机合成项目 在欧文的加州大学。 校长 调查人员将调查化学和物理 碳-碳双键的性质，即所谓的 烯基，在结构条件下， 在几何控制下的不饱和键， 定义条件。 属性的变化将被利用 来开发合成复杂结构的新方法。 碳-碳双键可能是最普遍存在的 有机化学中的官能团。 化学和 该官能团的光谱性质可以 通过将双键从 共面性 这个项目涉及分子的合成 含有扭曲的碳碳双键。 合成 这一努力使人们可以利用分子来研究 碳-碳双原子的化学和光谱性质 键对扭曲有反应 一个特别有趣 前景是确定可能 对特定的分子变形特别敏感。 它 也是利用具有扭曲双链的分子的意图， 键作为立体化学合成中的关键中间体 复杂的天然产品。

This research program of Dr. Kenneth J. Shea will be supported by the Organic Synthesis Program in the Department of Chemistry at the University of California at Irvine. The principal investigator will investigate the chemical and physical properties of the carbon-carbon double bond, the so-called olefinic group, under structural conditions that will distort the unsaturated linkage under geometrically controlled, well defined conditions. The changes in properties will be utilized to develop new methods of synthesizing complex structures. The carbon-carbon double bond is perhaps the most ubiquitous functional group in organic chemistry. The chemical and spectroscopic properties of this functional group may be significantly modified by twisting the double bond out of coplanarity. This project involves the synthesis of molecules that contain twisted carbon-carbon double bonds. The synthetic effort makes available molecules that permit study of how the chemical and spectroscopic properties of carbon-carbon double bonds respond to twisting. One particularly interesting prospect is to identify reaction manifolds that may be particularly sensitive to specific molecular deformations. It is also the intention to utilize molecules with twisted double bonds as key intermediates in the synthesis of stereochemically complex natural products.