Purchase of a 600 MHz NMR Spectrometer

有了化学研究仪器和设施(CRIF)计划的这一奖项，位于欧文的加利福尼亚大学化学系将获得一台600 MHz核磁共振光谱仪。该设备将使一些领域的研究成为可能，包括a)开发具有生物医学重要性的复杂分子的化学合成方法；b)蛋白质结构和相互作用的化学模型；c)结构测定和天然产物的合成；d)合成有机化学、新型聚合催化剂和有机硅酸盐化学；e)双核苷酸和双酪氨酸交联物的形成及其对短肽局部二级结构的影响；以及f)大生物分子内的氧化还原化学。核磁共振波谱是化学家用来阐明分子结构的最有力的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机化学和生物化学产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University in California in Irvine will acquire a 600 MHz NMR Spectrometer. This equipment will enable studies in a number of areas, including a) development of new methods for chemical synthesis of complex molecules of biomedical importance; b) chemical models of protein structures and interaction; c) structure determination and synthesis of natural products; d) synthetic organic chemistry, new polymerization catalysts, and organosiliconate chemistry; e) formation of ditryptophan and dityrosine crosslinks and their influence on local secondary structure in short peptides; and f) redox chemistry inside large bio-molecules. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry.