Purchase of a 600 MHz NMR Spectrometer

购买 600 MHz 核磁共振波谱仪

• 批准号: 0342937
• 负责人: Kenneth Shea
• 金额: $ 44.19万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0342937&HistoricalAwards=false
• 关键词: Purchase; 600; MHz; NMR; Spectrometer

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University in California in Irvine will acquire a 600 MHz NMR Spectrometer. This equipment will enable studies in a number of areas, including a) development of new methods for chemical synthesis of complex molecules of biomedical importance; b) chemical models of protein structures and interaction; c) structure determination and synthesis of natural products; d) synthetic organic chemistry, new polymerization catalysts, and organosiliconate chemistry; e) formation of ditryptophan and dityrosine crosslinks and their influence on local secondary structure in short peptides; and f) redox chemistry inside large bio-molecules. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry.

凭借化学研究仪器和设施（CRIF）计划的这一奖项，位于欧文的加州大学化学系将获得一台600 MHz NMR光谱仪。这一设备将有助于在若干领域进行研究，包括：（a）开发具有生物医学重要性的复杂分子的化学合成新方法;（B）蛋白质结构和相互作用的化学模型;（c）天然产品的结构测定和合成;（d）合成有机化学、新的聚合催化剂和有机硅酸酯化学; e）双色氨酸和双酪氨酸交联的形成及其对短肽中局部二级结构的影响;和f）大生物分子内的氧化还原化学。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机化学和生物化学产生影响。